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Recent Developments in HLA B27 Anterior Uveitis

There has been steady progress in understanding the pathogenesis, clinical features, and effective treatment of acute anterior uveitis (AU) over the past 5 years. Large gene wide association studies have confirmed that AU is a polygenic disease, with overlaps with the seronegative arthropathies and...

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Autores principales: Wakefield, Denis, Clarke, Daniel, McCluskey, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813675/
https://www.ncbi.nlm.nih.gov/pubmed/33469457
http://dx.doi.org/10.3389/fimmu.2020.608134
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author Wakefield, Denis
Clarke, Daniel
McCluskey, Peter
author_facet Wakefield, Denis
Clarke, Daniel
McCluskey, Peter
author_sort Wakefield, Denis
collection PubMed
description There has been steady progress in understanding the pathogenesis, clinical features, and effective treatment of acute anterior uveitis (AU) over the past 5 years. Large gene wide association studies have confirmed that AU is a polygenic disease, with overlaps with the seronegative arthropathies and inflammatory bowel diseases, associations that have been repeatedly confirmed in clinical studies. The role of the microbiome in AU has received increased research attention, with recent evidence indicating that human leukocyte antigen B27 (HLA B27) may influence the composition of the gut microbiome in experimental animals. Extensive clinical investigations have confirmed the typical features of acute AU (AAU) and its response to topical, regional and systemic immunosuppressive treatment. Increased understanding of the role of cytokines has resulted in studies confirming the value of anti-cytokine therapy [anti–tumor necrosis factor (anti-TNF) and interleukin 6 (IL-6) therapy] in severe and recurrent cases of AAU, particularly in subjects with an associated spondyloarthopathy (SpA) and in juvenile idiopathic arthritis (JIA)–associated AAU.
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spelling pubmed-78136752021-01-18 Recent Developments in HLA B27 Anterior Uveitis Wakefield, Denis Clarke, Daniel McCluskey, Peter Front Immunol Immunology There has been steady progress in understanding the pathogenesis, clinical features, and effective treatment of acute anterior uveitis (AU) over the past 5 years. Large gene wide association studies have confirmed that AU is a polygenic disease, with overlaps with the seronegative arthropathies and inflammatory bowel diseases, associations that have been repeatedly confirmed in clinical studies. The role of the microbiome in AU has received increased research attention, with recent evidence indicating that human leukocyte antigen B27 (HLA B27) may influence the composition of the gut microbiome in experimental animals. Extensive clinical investigations have confirmed the typical features of acute AU (AAU) and its response to topical, regional and systemic immunosuppressive treatment. Increased understanding of the role of cytokines has resulted in studies confirming the value of anti-cytokine therapy [anti–tumor necrosis factor (anti-TNF) and interleukin 6 (IL-6) therapy] in severe and recurrent cases of AAU, particularly in subjects with an associated spondyloarthopathy (SpA) and in juvenile idiopathic arthritis (JIA)–associated AAU. Frontiers Media S.A. 2021-01-05 /pmc/articles/PMC7813675/ /pubmed/33469457 http://dx.doi.org/10.3389/fimmu.2020.608134 Text en Copyright © 2021 Wakefield, Clarke and McCluskey http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wakefield, Denis
Clarke, Daniel
McCluskey, Peter
Recent Developments in HLA B27 Anterior Uveitis
title Recent Developments in HLA B27 Anterior Uveitis
title_full Recent Developments in HLA B27 Anterior Uveitis
title_fullStr Recent Developments in HLA B27 Anterior Uveitis
title_full_unstemmed Recent Developments in HLA B27 Anterior Uveitis
title_short Recent Developments in HLA B27 Anterior Uveitis
title_sort recent developments in hla b27 anterior uveitis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813675/
https://www.ncbi.nlm.nih.gov/pubmed/33469457
http://dx.doi.org/10.3389/fimmu.2020.608134
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