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Copper Levels in Patients with Unexplained Dysplastic Cytopenia

Copper deficiency can produce changes mimicking myelodysplasia, but its prevalence among haematology patients is unknown. This study evaluates the prevalence of deficiency in a population of patients with unexplained cytopenia(s) and dysplasia. Of 17 patients recruited, only one was found to have a...

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Autores principales: Butcher, Dominic, Deplano, Simona, Lofaro, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813699/
https://www.ncbi.nlm.nih.gov/pubmed/32483693
http://dx.doi.org/10.1007/s12011-020-02203-x
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author Butcher, Dominic
Deplano, Simona
Lofaro, Thomas
author_facet Butcher, Dominic
Deplano, Simona
Lofaro, Thomas
author_sort Butcher, Dominic
collection PubMed
description Copper deficiency can produce changes mimicking myelodysplasia, but its prevalence among haematology patients is unknown. This study evaluates the prevalence of deficiency in a population of patients with unexplained cytopenia(s) and dysplasia. Of 17 patients recruited, only one was found to have a low copper level. This is the first study evaluating hypocupremia in patients with isolated haematological manifestations. Our results suggest that copper deficiency is uncommon in this population, and the routine measurement of copper seems unlikely to be cost-effective. We recommend a risk-assessed approach to testing based on the identification of risk factors and of signs suggestive of deficiency. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12011-020-02203-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-78136992021-01-25 Copper Levels in Patients with Unexplained Dysplastic Cytopenia Butcher, Dominic Deplano, Simona Lofaro, Thomas Biol Trace Elem Res Article Copper deficiency can produce changes mimicking myelodysplasia, but its prevalence among haematology patients is unknown. This study evaluates the prevalence of deficiency in a population of patients with unexplained cytopenia(s) and dysplasia. Of 17 patients recruited, only one was found to have a low copper level. This is the first study evaluating hypocupremia in patients with isolated haematological manifestations. Our results suggest that copper deficiency is uncommon in this population, and the routine measurement of copper seems unlikely to be cost-effective. We recommend a risk-assessed approach to testing based on the identification of risk factors and of signs suggestive of deficiency. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12011-020-02203-x) contains supplementary material, which is available to authorized users. Springer US 2020-06-02 2021 /pmc/articles/PMC7813699/ /pubmed/32483693 http://dx.doi.org/10.1007/s12011-020-02203-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Butcher, Dominic
Deplano, Simona
Lofaro, Thomas
Copper Levels in Patients with Unexplained Dysplastic Cytopenia
title Copper Levels in Patients with Unexplained Dysplastic Cytopenia
title_full Copper Levels in Patients with Unexplained Dysplastic Cytopenia
title_fullStr Copper Levels in Patients with Unexplained Dysplastic Cytopenia
title_full_unstemmed Copper Levels in Patients with Unexplained Dysplastic Cytopenia
title_short Copper Levels in Patients with Unexplained Dysplastic Cytopenia
title_sort copper levels in patients with unexplained dysplastic cytopenia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813699/
https://www.ncbi.nlm.nih.gov/pubmed/32483693
http://dx.doi.org/10.1007/s12011-020-02203-x
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