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Yarrowia lipolytica as an Oleaginous Platform for the Production of Value-Added Fatty Acid-Based Bioproducts

The microbial fermentation process has been used as an alternative pathway to the production of value-added natural products. Of the microorganisms, Yarrowia lipolytica, as an oleaginous platform, is able to produce fatty acid-derived biofuels and biochemicals. Nowadays, there are growing progresses...

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Autores principales: Liu, Huhu, Song, Yulan, Fan, Xiao, Wang, Chong, Lu, Xiangyang, Tian, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813756/
https://www.ncbi.nlm.nih.gov/pubmed/33469452
http://dx.doi.org/10.3389/fmicb.2020.608662
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author Liu, Huhu
Song, Yulan
Fan, Xiao
Wang, Chong
Lu, Xiangyang
Tian, Yun
author_facet Liu, Huhu
Song, Yulan
Fan, Xiao
Wang, Chong
Lu, Xiangyang
Tian, Yun
author_sort Liu, Huhu
collection PubMed
description The microbial fermentation process has been used as an alternative pathway to the production of value-added natural products. Of the microorganisms, Yarrowia lipolytica, as an oleaginous platform, is able to produce fatty acid-derived biofuels and biochemicals. Nowadays, there are growing progresses on the production of value-added fatty acid-based bioproducts in Y. lipolytica. However, there are fewer reviews performing the metabolic engineering strategies and summarizing the current production of fatty acid-based bioproducts in Y. lipolytica. To this end, we briefly provide the fatty acid metabolism, including fatty acid biosynthesis, transportation, and degradation. Then, we introduce the various metabolic engineering strategies for increasing bioproduct accumulation in Y. lipolytica. Further, the advanced progress in the production of fatty acid-based bioproducts by Y. lipolytica, including nutraceuticals, biofuels, and biochemicals, is summarized. This review will provide attractive thoughts for researchers working in the field of Y. lipolytica.
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spelling pubmed-78137562021-01-18 Yarrowia lipolytica as an Oleaginous Platform for the Production of Value-Added Fatty Acid-Based Bioproducts Liu, Huhu Song, Yulan Fan, Xiao Wang, Chong Lu, Xiangyang Tian, Yun Front Microbiol Microbiology The microbial fermentation process has been used as an alternative pathway to the production of value-added natural products. Of the microorganisms, Yarrowia lipolytica, as an oleaginous platform, is able to produce fatty acid-derived biofuels and biochemicals. Nowadays, there are growing progresses on the production of value-added fatty acid-based bioproducts in Y. lipolytica. However, there are fewer reviews performing the metabolic engineering strategies and summarizing the current production of fatty acid-based bioproducts in Y. lipolytica. To this end, we briefly provide the fatty acid metabolism, including fatty acid biosynthesis, transportation, and degradation. Then, we introduce the various metabolic engineering strategies for increasing bioproduct accumulation in Y. lipolytica. Further, the advanced progress in the production of fatty acid-based bioproducts by Y. lipolytica, including nutraceuticals, biofuels, and biochemicals, is summarized. This review will provide attractive thoughts for researchers working in the field of Y. lipolytica. Frontiers Media S.A. 2021-01-05 /pmc/articles/PMC7813756/ /pubmed/33469452 http://dx.doi.org/10.3389/fmicb.2020.608662 Text en Copyright © 2021 Liu, Song, Fan, Wang, Lu and Tian. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Liu, Huhu
Song, Yulan
Fan, Xiao
Wang, Chong
Lu, Xiangyang
Tian, Yun
Yarrowia lipolytica as an Oleaginous Platform for the Production of Value-Added Fatty Acid-Based Bioproducts
title Yarrowia lipolytica as an Oleaginous Platform for the Production of Value-Added Fatty Acid-Based Bioproducts
title_full Yarrowia lipolytica as an Oleaginous Platform for the Production of Value-Added Fatty Acid-Based Bioproducts
title_fullStr Yarrowia lipolytica as an Oleaginous Platform for the Production of Value-Added Fatty Acid-Based Bioproducts
title_full_unstemmed Yarrowia lipolytica as an Oleaginous Platform for the Production of Value-Added Fatty Acid-Based Bioproducts
title_short Yarrowia lipolytica as an Oleaginous Platform for the Production of Value-Added Fatty Acid-Based Bioproducts
title_sort yarrowia lipolytica as an oleaginous platform for the production of value-added fatty acid-based bioproducts
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813756/
https://www.ncbi.nlm.nih.gov/pubmed/33469452
http://dx.doi.org/10.3389/fmicb.2020.608662
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