Inhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson’s disease

Wilson’s disease (WD) is an inherited disorder characterized by excessive accumulation of copper in the body, particularly in the liver and brain. In the central nervous system (CNS), extracellular copper accumulation triggers pathological microglial activation and subsequent neurotoxicity. Growing...

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Detalles Bibliográficos
Autores principales: Dong, Jianjian, Wang, Xun, Xu, Chenchen, Gao, Manli, Wang, Shijing, Zhang, Jin, Tong, Haiyang, Wang, Lulu, Han, Yongzhu, Cheng, Nan, Han, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813851/
https://www.ncbi.nlm.nih.gov/pubmed/33462188
http://dx.doi.org/10.1038/s41419-021-03397-1

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