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Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin

The serotonin transporter (SLC6A4), 5-HT(2A) (HTR2A) and 5-HT(2B) (HTR2B) recepter genes, express proteins that are important regulators of serotonin reuptake and signaling, and thereby may contribute to the pathogenesis of aggressive criminal behavior. 370 sentenced murderers in Pakistani prisons a...

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Autores principales: Qadeer, Muhammad Imran, Amar, Ali, Huang, Yung-Yu, Min, Eli, Galfalvy, Hanga, Hasnain, Shahida, Mann, J. John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813852/
https://www.ncbi.nlm.nih.gov/pubmed/33462318
http://dx.doi.org/10.1038/s41598-021-81198-4
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author Qadeer, Muhammad Imran
Amar, Ali
Huang, Yung-Yu
Min, Eli
Galfalvy, Hanga
Hasnain, Shahida
Mann, J. John
author_facet Qadeer, Muhammad Imran
Amar, Ali
Huang, Yung-Yu
Min, Eli
Galfalvy, Hanga
Hasnain, Shahida
Mann, J. John
author_sort Qadeer, Muhammad Imran
collection PubMed
description The serotonin transporter (SLC6A4), 5-HT(2A) (HTR2A) and 5-HT(2B) (HTR2B) recepter genes, express proteins that are important regulators of serotonin reuptake and signaling, and thereby may contribute to the pathogenesis of aggressive criminal behavior. 370 sentenced murderers in Pakistani prisons and 359 men without any history of violence or criminal delinquency were genotyped for six candidate polymorphisms in SLC6A4, HTR2A and HTR2B genes. An association of higher expressing L/L and L(A)/L(A) variants of the 5-HTTLPR polymorphism was observed with homicidal behavior (bi-allelic: OR = 1.29, p = 0.016, tri-allelic: OR = 1.32, p = 0.015) and in the murderer group only with response to verbal abuse (OR = 2.11, p = 0.015), but not with other measures of self-reported aggression. L/L and L(A)/L(A) genotypes of the 5-HTTLPR polymorphism were associated with higher aggression scores on STAX1 scale of aggression compared to lower expressing genotypes (S/S, S/L(G), L(G)/L(G)) in prison inmates. No associations were apparent for other serotonergic gene polymorphisms analyzed. Using the Braineac and GTEx databases, we demonstrated significant eQTL based functional effects for rs25531 in HTTLPR and other serotonergic polymorphisms analyzed in different brain regions and peripheral tissues. In conclusion, these findings implicate SLC6A4* HTTLPR as a major genetic determinant associated with criminal aggression. Future studies are needed to replicate this finding and establish the biologic intermediate phenotypes mediating this relationship.
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spelling pubmed-78138522021-01-21 Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin Qadeer, Muhammad Imran Amar, Ali Huang, Yung-Yu Min, Eli Galfalvy, Hanga Hasnain, Shahida Mann, J. John Sci Rep Article The serotonin transporter (SLC6A4), 5-HT(2A) (HTR2A) and 5-HT(2B) (HTR2B) recepter genes, express proteins that are important regulators of serotonin reuptake and signaling, and thereby may contribute to the pathogenesis of aggressive criminal behavior. 370 sentenced murderers in Pakistani prisons and 359 men without any history of violence or criminal delinquency were genotyped for six candidate polymorphisms in SLC6A4, HTR2A and HTR2B genes. An association of higher expressing L/L and L(A)/L(A) variants of the 5-HTTLPR polymorphism was observed with homicidal behavior (bi-allelic: OR = 1.29, p = 0.016, tri-allelic: OR = 1.32, p = 0.015) and in the murderer group only with response to verbal abuse (OR = 2.11, p = 0.015), but not with other measures of self-reported aggression. L/L and L(A)/L(A) genotypes of the 5-HTTLPR polymorphism were associated with higher aggression scores on STAX1 scale of aggression compared to lower expressing genotypes (S/S, S/L(G), L(G)/L(G)) in prison inmates. No associations were apparent for other serotonergic gene polymorphisms analyzed. Using the Braineac and GTEx databases, we demonstrated significant eQTL based functional effects for rs25531 in HTTLPR and other serotonergic polymorphisms analyzed in different brain regions and peripheral tissues. In conclusion, these findings implicate SLC6A4* HTTLPR as a major genetic determinant associated with criminal aggression. Future studies are needed to replicate this finding and establish the biologic intermediate phenotypes mediating this relationship. Nature Publishing Group UK 2021-01-18 /pmc/articles/PMC7813852/ /pubmed/33462318 http://dx.doi.org/10.1038/s41598-021-81198-4 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Qadeer, Muhammad Imran
Amar, Ali
Huang, Yung-Yu
Min, Eli
Galfalvy, Hanga
Hasnain, Shahida
Mann, J. John
Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title_full Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title_fullStr Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title_full_unstemmed Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title_short Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin
title_sort association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of pakistani origin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7813852/
https://www.ncbi.nlm.nih.gov/pubmed/33462318
http://dx.doi.org/10.1038/s41598-021-81198-4
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