A conjoined universal helper epitope can unveil antitumor effects of a neoantigen vaccine targeting an MHC class I-restricted neoepitope

Personalized cancer vaccines targeting neoantigens arising from somatic missense mutations are currently being evaluated for the treatment of various cancers due to their potential to elicit a multivalent, tumor-specific immune response. Several cancers express a low number of neoantigens; in these...

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Detalles Bibliográficos
Autores principales: Swartz, Adam M., Congdon, Kendra L., Nair, Smita K., Li, Qi-Jing, Herndon, James E., Suryadevara, Carter M., Riccione, Katherine A., Archer, Gary E., Norberg, Pamela K., Sanchez-Perez, Luis A., Sampson, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814002/
https://www.ncbi.nlm.nih.gov/pubmed/33462231
http://dx.doi.org/10.1038/s41541-020-00273-5

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