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2,2-difluorovinyl benzoates for diverse synthesis of gem-difluoroenol ethers by Ni-catalyzed cross-coupling reactions

gem-Difluoroalkene is a bioisostere of carbonyl group for improving bioavailability of drug candidates. Herein we develop structurally diverse 2,2-difluorovinyl benzoates (BzO-DFs) as versatile building blocks for modular synthesis of gem-difluoroenol ethers (44 examples) and gem-difluoroalkenes (2...

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Detalles Bibliográficos
Autores principales:	Du, Bingnan, Chan, Chun-Ming, Lee, Pui-Yiu, Cheung, Leong-Hung, Xu, Xin, Lin, Zhenyang, Yu, Wing-Yiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814061/ https://www.ncbi.nlm.nih.gov/pubmed/33462244 http://dx.doi.org/10.1038/s41467-020-20725-9

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