Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane

An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibits a broad reaction scope, a simple operation and without the need of any expensive transition-metal catalyst,...

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Autores principales: Karuo, Yukiko, Kametani, Ayaka, Tarui, Atsushi, Sato, Kazuyuki, Kawai, Kentaro, Omote, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2021
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814179/
https://www.ncbi.nlm.nih.gov/pubmed/33519995
http://dx.doi.org/10.3762/bjoc.17.9
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author Karuo, Yukiko
Kametani, Ayaka
Tarui, Atsushi
Sato, Kazuyuki
Kawai, Kentaro
Omote, Masaaki
author_facet Karuo, Yukiko
Kametani, Ayaka
Tarui, Atsushi
Sato, Kazuyuki
Kawai, Kentaro
Omote, Masaaki
author_sort Karuo, Yukiko
collection PubMed
description An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibits a broad reaction scope, a simple operation and without the need of any expensive transition-metal catalyst, highly toxic or corrosive reagents. Notably, we demonstrate the potential utility of halothane for the synthesis of aryl gem-difluoroalkyl ethers containing the bromochloromethyl group.
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spelling pubmed-78141792021-01-29 Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane Karuo, Yukiko Kametani, Ayaka Tarui, Atsushi Sato, Kazuyuki Kawai, Kentaro Omote, Masaaki Beilstein J Org Chem Full Research Paper An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibits a broad reaction scope, a simple operation and without the need of any expensive transition-metal catalyst, highly toxic or corrosive reagents. Notably, we demonstrate the potential utility of halothane for the synthesis of aryl gem-difluoroalkyl ethers containing the bromochloromethyl group. Beilstein-Institut 2021-01-11 /pmc/articles/PMC7814179/ /pubmed/33519995 http://dx.doi.org/10.3762/bjoc.17.9 Text en Copyright © 2021, Karuo et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/terms/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the author(s) and source are credited and that individual graphics may be subject to special legal provisions. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms/terms)
spellingShingle Full Research Paper
Karuo, Yukiko
Kametani, Ayaka
Tarui, Atsushi
Sato, Kazuyuki
Kawai, Kentaro
Omote, Masaaki
Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane
title Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane
title_full Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane
title_fullStr Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane
title_full_unstemmed Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane
title_short Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane
title_sort synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814179/
https://www.ncbi.nlm.nih.gov/pubmed/33519995
http://dx.doi.org/10.3762/bjoc.17.9
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