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Adjunctive Statin Therapy Reduces Mortality After Acute Hemorrhagic Stroke

BACKGROUND: Statin treatment improves clinical outcomes in patients with ischemic strokes, although there is no evidence regarding the safety of statin therapy in patients with intracerebral hemorrhage (ICH). This study aimed at evaluating the effects of continuing statin treatment after ICH. METHOD...

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Autores principales: Lin, Cheng-Kai, Chen, Po-Yuan, Wu, Yu-ying, Wu, Cheng-Chun, Chen, Han-Jung, Liang, Cheng-Loong, Lee, Yi-Che, Lin, Chi-Wei, Hung, Chao-Ming, Wang, Hao-Kuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814233/
https://www.ncbi.nlm.nih.gov/pubmed/33488130
http://dx.doi.org/10.2147/RMHP.S290964
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author Lin, Cheng-Kai
Chen, Po-Yuan
Wu, Yu-ying
Wu, Cheng-Chun
Chen, Han-Jung
Liang, Cheng-Loong
Lee, Yi-Che
Lin, Chi-Wei
Hung, Chao-Ming
Wang, Hao-Kuang
author_facet Lin, Cheng-Kai
Chen, Po-Yuan
Wu, Yu-ying
Wu, Cheng-Chun
Chen, Han-Jung
Liang, Cheng-Loong
Lee, Yi-Che
Lin, Chi-Wei
Hung, Chao-Ming
Wang, Hao-Kuang
author_sort Lin, Cheng-Kai
collection PubMed
description BACKGROUND: Statin treatment improves clinical outcomes in patients with ischemic strokes, although there is no evidence regarding the safety of statin therapy in patients with intracerebral hemorrhage (ICH). This study aimed at evaluating the effects of continuing statin treatment after ICH. METHODS: Data were obtained from the National Health Insurance Research Database in Taiwan. We retrospectively compared the data of patients with and without statin exposure after ICH. The outcomes of interest were recurrence of hemorrhagic stroke and mortality during a follow-up period of 10 years. RESULTS: During the 10-year follow-up period, the mortality rate was 32.73% in the statin group and 42.77% in the non-statin group. Statin therapy in patients with acute ICH with dyslipidemia can decrease mortality. CONCLUSION: Statin therapy reduced the risk of 10-year mortality in patients who experienced acute hemorrhagic stroke.
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spelling pubmed-78142332021-01-21 Adjunctive Statin Therapy Reduces Mortality After Acute Hemorrhagic Stroke Lin, Cheng-Kai Chen, Po-Yuan Wu, Yu-ying Wu, Cheng-Chun Chen, Han-Jung Liang, Cheng-Loong Lee, Yi-Che Lin, Chi-Wei Hung, Chao-Ming Wang, Hao-Kuang Risk Manag Healthc Policy Original Research BACKGROUND: Statin treatment improves clinical outcomes in patients with ischemic strokes, although there is no evidence regarding the safety of statin therapy in patients with intracerebral hemorrhage (ICH). This study aimed at evaluating the effects of continuing statin treatment after ICH. METHODS: Data were obtained from the National Health Insurance Research Database in Taiwan. We retrospectively compared the data of patients with and without statin exposure after ICH. The outcomes of interest were recurrence of hemorrhagic stroke and mortality during a follow-up period of 10 years. RESULTS: During the 10-year follow-up period, the mortality rate was 32.73% in the statin group and 42.77% in the non-statin group. Statin therapy in patients with acute ICH with dyslipidemia can decrease mortality. CONCLUSION: Statin therapy reduced the risk of 10-year mortality in patients who experienced acute hemorrhagic stroke. Dove 2021-01-14 /pmc/articles/PMC7814233/ /pubmed/33488130 http://dx.doi.org/10.2147/RMHP.S290964 Text en © 2021 Lin et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Lin, Cheng-Kai
Chen, Po-Yuan
Wu, Yu-ying
Wu, Cheng-Chun
Chen, Han-Jung
Liang, Cheng-Loong
Lee, Yi-Che
Lin, Chi-Wei
Hung, Chao-Ming
Wang, Hao-Kuang
Adjunctive Statin Therapy Reduces Mortality After Acute Hemorrhagic Stroke
title Adjunctive Statin Therapy Reduces Mortality After Acute Hemorrhagic Stroke
title_full Adjunctive Statin Therapy Reduces Mortality After Acute Hemorrhagic Stroke
title_fullStr Adjunctive Statin Therapy Reduces Mortality After Acute Hemorrhagic Stroke
title_full_unstemmed Adjunctive Statin Therapy Reduces Mortality After Acute Hemorrhagic Stroke
title_short Adjunctive Statin Therapy Reduces Mortality After Acute Hemorrhagic Stroke
title_sort adjunctive statin therapy reduces mortality after acute hemorrhagic stroke
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814233/
https://www.ncbi.nlm.nih.gov/pubmed/33488130
http://dx.doi.org/10.2147/RMHP.S290964
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