Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions

Nuclear import receptors, also called importins, mediate nuclear import of proteins and chaperone aggregation-prone cargoes (e.g., neurodegeneration-linked RNA-binding proteins [RBPs]) in the cytoplasm. Importins were identified as modulators of cellular toxicity elicited by arginine-rich dipeptide...

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Detalles Bibliográficos
Autores principales: Hutten, Saskia, Usluer, Sinem, Bourgeois, Benjamin, Simonetti, Francesca, Odeh, Hana M., Fare, Charlotte M., Czuppa, Mareike, Hruska-Plochan, Marian, Hofweber, Mario, Polymenidou, Magdalini, Shorter, James, Edbauer, Dieter, Madl, Tobias, Dormann, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814465/
https://www.ncbi.nlm.nih.gov/pubmed/33357437
http://dx.doi.org/10.1016/j.celrep.2020.108538

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