Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats

BACKGROUND: Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of hypoxic-ischemic (HI)-induced brain injury. Activation of melanocortin-1 receptor (MC1R) has been shown to exert anti-inflammatory and neuroprotective effects in several neurological diseases. In the present...

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Detalles Bibliográficos
Autores principales: Yu, Shufeng, Doycheva, Desislava Met, Gamdzyk, Marcin, Yang, Yijun, Lenahan, Cameron, Li, Gaigai, Li, Dujuan, Lian, Lifei, Tang, Jiping, Lu, Jun, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814630/
https://www.ncbi.nlm.nih.gov/pubmed/33468172
http://dx.doi.org/10.1186/s12974-021-02078-2

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