Cargando…
rs1990622 variant associates with Alzheimer’s disease and regulates TMEM106B expression in human brain tissues
BACKGROUND: It has been well established that the TMEM106B gene rs1990622 variant was a frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the role of TMEM106B in Alzheimer’s disease (AD). However, it remains largely unclear about the role of rs1990622 variant in...
Autores principales: | Hu, Yang, Sun, Jing-yi, Zhang, Yan, Zhang, Haihua, Gao, Shan, Wang, Tao, Han, Zhifa, Wang, Longcai, Sun, Bao-liang, Liu, Guiyou |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814705/ https://www.ncbi.nlm.nih.gov/pubmed/33461566 http://dx.doi.org/10.1186/s12916-020-01883-5 |
Ejemplares similares
-
Mendelian randomization highlights significant difference and genetic heterogeneity in clinically diagnosed Alzheimer’s disease GWAS and self-report proxy phenotype GWAX
por: Liu, Haijie, et al.
Publicado: (2022) -
Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer’s disease
por: Liu, Haijie, et al.
Publicado: (2021) -
Effect of plasma vitamin C levels on Parkinson’s disease and age at onset: a Mendelian randomization study
por: Liu, Haijie, et al.
Publicado: (2021) -
TMEM106B expression is reduced in Alzheimer’s disease brains
por: Satoh, Jun-ichi, et al.
Publicado: (2014) -
C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes
por: T. Vicente, Cristina, et al.
Publicado: (2023)