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Effective connectivity between bed nucleus of the stria terminalis and amygdala: Reproducibility and relation to anxiety

In a previous study, we investigated the resting‐state fMRI effective connectivity (EC) between the bed nucleus of the stria terminalis (BNST) and the laterobasal (LB), centromedial (CM), and superficial (SF) amygdala. We found strong negative EC from all amygdala nuclei to the BNST, while the BNST...

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Autores principales: Hofmann, David, Straube, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814768/
https://www.ncbi.nlm.nih.gov/pubmed/33155747
http://dx.doi.org/10.1002/hbm.25265
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author Hofmann, David
Straube, Thomas
author_facet Hofmann, David
Straube, Thomas
author_sort Hofmann, David
collection PubMed
description In a previous study, we investigated the resting‐state fMRI effective connectivity (EC) between the bed nucleus of the stria terminalis (BNST) and the laterobasal (LB), centromedial (CM), and superficial (SF) amygdala. We found strong negative EC from all amygdala nuclei to the BNST, while the BNST showed positive EC to the amygdala. However, the validity of these findings remains unclear, since a reproduction in different samples has not been done. Moreover, the association of EC with measures of anxiety offers deeper insight, due to the known role of the BNST and amygdala in fear and anxiety. Here, we aimed to reproduce our previous results in three additional samples. We used spectral Dynamic Causal Modeling to estimate the EC between the BNST, the LB, CM, and SF, and its association with two measures of self‐reported anxiety. Our results revealed consistency over samples with regard to the negative EC from the amygdala nuclei to the BNST, while the positive EC from BNST to the amygdala was also found, but weaker and more heterogenic. Moreover, we found the BNST‐BNST EC showing a positive and the CM‐BNST EC, showing a negative association with anxiety. Our study suggests a reproducible pattern of negative EC from the amygdala to the BNST along with weaker positive EC from the BNST to the amygdala. Moreover, less BNST self‐inhibition and more inhibitory influence from the CM to the BNST seems to be a pattern of EC that is related to higher anxiety.
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spelling pubmed-78147682021-01-26 Effective connectivity between bed nucleus of the stria terminalis and amygdala: Reproducibility and relation to anxiety Hofmann, David Straube, Thomas Hum Brain Mapp Research Articles In a previous study, we investigated the resting‐state fMRI effective connectivity (EC) between the bed nucleus of the stria terminalis (BNST) and the laterobasal (LB), centromedial (CM), and superficial (SF) amygdala. We found strong negative EC from all amygdala nuclei to the BNST, while the BNST showed positive EC to the amygdala. However, the validity of these findings remains unclear, since a reproduction in different samples has not been done. Moreover, the association of EC with measures of anxiety offers deeper insight, due to the known role of the BNST and amygdala in fear and anxiety. Here, we aimed to reproduce our previous results in three additional samples. We used spectral Dynamic Causal Modeling to estimate the EC between the BNST, the LB, CM, and SF, and its association with two measures of self‐reported anxiety. Our results revealed consistency over samples with regard to the negative EC from the amygdala nuclei to the BNST, while the positive EC from BNST to the amygdala was also found, but weaker and more heterogenic. Moreover, we found the BNST‐BNST EC showing a positive and the CM‐BNST EC, showing a negative association with anxiety. Our study suggests a reproducible pattern of negative EC from the amygdala to the BNST along with weaker positive EC from the BNST to the amygdala. Moreover, less BNST self‐inhibition and more inhibitory influence from the CM to the BNST seems to be a pattern of EC that is related to higher anxiety. John Wiley & Sons, Inc. 2020-11-06 /pmc/articles/PMC7814768/ /pubmed/33155747 http://dx.doi.org/10.1002/hbm.25265 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Hofmann, David
Straube, Thomas
Effective connectivity between bed nucleus of the stria terminalis and amygdala: Reproducibility and relation to anxiety
title Effective connectivity between bed nucleus of the stria terminalis and amygdala: Reproducibility and relation to anxiety
title_full Effective connectivity between bed nucleus of the stria terminalis and amygdala: Reproducibility and relation to anxiety
title_fullStr Effective connectivity between bed nucleus of the stria terminalis and amygdala: Reproducibility and relation to anxiety
title_full_unstemmed Effective connectivity between bed nucleus of the stria terminalis and amygdala: Reproducibility and relation to anxiety
title_short Effective connectivity between bed nucleus of the stria terminalis and amygdala: Reproducibility and relation to anxiety
title_sort effective connectivity between bed nucleus of the stria terminalis and amygdala: reproducibility and relation to anxiety
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814768/
https://www.ncbi.nlm.nih.gov/pubmed/33155747
http://dx.doi.org/10.1002/hbm.25265
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