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The role of plasma genotyping in ALK- and ROS1-rearranged lung cancer

Several subsets of non-small cell lung cancer (NSCLC) are defined by the presence of oncogenic rearrangements that result in constitutive activation of a chimeric fusion protein. In NSCLCs that harbor ALK or ROS1 rearrangements, aberrant signaling from these fusion proteins can be overcome by potent...

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Detalles Bibliográficos
Autores principales:	Dagogo-Jack, Ibiayi, Ritterhouse, Lauren L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Review Article on Looking for Chimeras in NSCLC: Widen Therapeutic Options Targeting Oncogenic Fusions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815348/ https://www.ncbi.nlm.nih.gov/pubmed/33489818 http://dx.doi.org/10.21037/tlcr-2019-cnsclc-09

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