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Metformin reverses chemoresistance in non-small cell lung cancer via accelerating ubiquitination-mediated degradation of Nrf2

BACKGROUND: The therapeutic efficacy of cisplatin-based chemotherapy for non-small cell lung cancer (NSCLC) is limited by drug resistance. In NSCLC, hyperactivation of nuclear factor erythroid 2-related factor 2 (Nrf2) counteracts oxidative stress to promote chemoresistance. Metformin-mediated downr...

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Detalles Bibliográficos
Autores principales:	Huang, Sha, He, Tianyu, Yang, Sijia, Sheng, Hongxu, Tang, Xiuwen, Bao, Feichao, Wang, Yiqing, Lin, Xu, Yu, Wenfeng, Cheng, Fei, Lv, Wang, Hu, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815349/ https://www.ncbi.nlm.nih.gov/pubmed/33489797 http://dx.doi.org/10.21037/tlcr-20-1072

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