Venetoclax Combined with Hypomethylating Agents for Treatment-Naïve B/Myeloid Mixed Phenotype Acute Leukemia

Mixed phenotype acute leukemia (MPAL) is a rare hematological malignancy that lacks consensus on optimal management. We report for the first time two cases of treatment-naïve B/myeloid MPAL patients treated with a novel chemo-free regimen using venetoclax combined with hypomethylating agents, which...

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Detalles Bibliográficos
Autores principales: Wu, Di, Chen, Wenlan, Chen, Zhichao, Li, Qiubai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815380/
https://www.ncbi.nlm.nih.gov/pubmed/33505737
http://dx.doi.org/10.1155/2021/6661109
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author Wu, Di
Chen, Wenlan
Chen, Zhichao
Li, Qiubai
author_facet Wu, Di
Chen, Wenlan
Chen, Zhichao
Li, Qiubai
author_sort Wu, Di
collection PubMed
description Mixed phenotype acute leukemia (MPAL) is a rare hematological malignancy that lacks consensus on optimal management. We report for the first time two cases of treatment-naïve B/myeloid MPAL patients treated with a novel chemo-free regimen using venetoclax combined with hypomethylating agents, which successfully induced complete remission with tolerable toxicities.
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spelling pubmed-78153802021-01-26 Venetoclax Combined with Hypomethylating Agents for Treatment-Naïve B/Myeloid Mixed Phenotype Acute Leukemia Wu, Di Chen, Wenlan Chen, Zhichao Li, Qiubai Case Rep Hematol Case Report Mixed phenotype acute leukemia (MPAL) is a rare hematological malignancy that lacks consensus on optimal management. We report for the first time two cases of treatment-naïve B/myeloid MPAL patients treated with a novel chemo-free regimen using venetoclax combined with hypomethylating agents, which successfully induced complete remission with tolerable toxicities. Hindawi 2021-01-12 /pmc/articles/PMC7815380/ /pubmed/33505737 http://dx.doi.org/10.1155/2021/6661109 Text en Copyright © 2021 Di Wu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Wu, Di
Chen, Wenlan
Chen, Zhichao
Li, Qiubai
Venetoclax Combined with Hypomethylating Agents for Treatment-Naïve B/Myeloid Mixed Phenotype Acute Leukemia
title Venetoclax Combined with Hypomethylating Agents for Treatment-Naïve B/Myeloid Mixed Phenotype Acute Leukemia
title_full Venetoclax Combined with Hypomethylating Agents for Treatment-Naïve B/Myeloid Mixed Phenotype Acute Leukemia
title_fullStr Venetoclax Combined with Hypomethylating Agents for Treatment-Naïve B/Myeloid Mixed Phenotype Acute Leukemia
title_full_unstemmed Venetoclax Combined with Hypomethylating Agents for Treatment-Naïve B/Myeloid Mixed Phenotype Acute Leukemia
title_short Venetoclax Combined with Hypomethylating Agents for Treatment-Naïve B/Myeloid Mixed Phenotype Acute Leukemia
title_sort venetoclax combined with hypomethylating agents for treatment-naïve b/myeloid mixed phenotype acute leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815380/
https://www.ncbi.nlm.nih.gov/pubmed/33505737
http://dx.doi.org/10.1155/2021/6661109
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AT chenzhichao venetoclaxcombinedwithhypomethylatingagentsfortreatmentnaivebmyeloidmixedphenotypeacuteleukemia
AT liqiubai venetoclaxcombinedwithhypomethylatingagentsfortreatmentnaivebmyeloidmixedphenotypeacuteleukemia

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