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Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment

Kefir drink is one of the most important probiotic products, which is made using kefir microorganisms in fermenting the milk. Numerous investigation have been accomplished in the field of the therapeutic property of probiotic products. In the present study, we assessed the cytotoxic effect of kefir...

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Detalles Bibliográficos
Autores principales: Fatahi, Arghavan, Soleimani, Neda, Afrough, Parviz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815417/
https://www.ncbi.nlm.nih.gov/pubmed/33506004
http://dx.doi.org/10.1155/2021/8180742
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author Fatahi, Arghavan
Soleimani, Neda
Afrough, Parviz
author_facet Fatahi, Arghavan
Soleimani, Neda
Afrough, Parviz
author_sort Fatahi, Arghavan
collection PubMed
description Kefir drink is one of the most important probiotic products, which is made using kefir microorganisms in fermenting the milk. Numerous investigation have been accomplished in the field of the therapeutic property of probiotic products. In the present study, we assessed the cytotoxic effect of kefir on the rate of growth and increase of glioblastoma cancer cell as the most severe form of brain tumors. In this experimental study, we used a U87 cancer cell line (glioblastoma). The interaction between cancer cells and different concentrations of kefir drink and supernatants at 24 and 48 hours was considered. The cell cytotoxicity of kefir and sedimentation of cell lysate and extract of kefir was assessed using the MTT test after 24 and 48 hours. The result of the MTT test, treatment of the cells with the 48-hour fermented drink, demonstrated the most cell cytotoxicity in comparison with the control group. Results showed that the toxicity effect in all groups was dose-dependent, and by increasing the concentration, cell survival decreased noticeably. The results indicated that the supernatant of fermented kefir drink as a probiotic product has more toxicity and lethality effect on the glioblastoma cancer cell. This product can be utilized as a replacement or a complementary therapy of cancer.
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spelling pubmed-78154172021-01-26 Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment Fatahi, Arghavan Soleimani, Neda Afrough, Parviz Int J Food Sci Research Article Kefir drink is one of the most important probiotic products, which is made using kefir microorganisms in fermenting the milk. Numerous investigation have been accomplished in the field of the therapeutic property of probiotic products. In the present study, we assessed the cytotoxic effect of kefir on the rate of growth and increase of glioblastoma cancer cell as the most severe form of brain tumors. In this experimental study, we used a U87 cancer cell line (glioblastoma). The interaction between cancer cells and different concentrations of kefir drink and supernatants at 24 and 48 hours was considered. The cell cytotoxicity of kefir and sedimentation of cell lysate and extract of kefir was assessed using the MTT test after 24 and 48 hours. The result of the MTT test, treatment of the cells with the 48-hour fermented drink, demonstrated the most cell cytotoxicity in comparison with the control group. Results showed that the toxicity effect in all groups was dose-dependent, and by increasing the concentration, cell survival decreased noticeably. The results indicated that the supernatant of fermented kefir drink as a probiotic product has more toxicity and lethality effect on the glioblastoma cancer cell. This product can be utilized as a replacement or a complementary therapy of cancer. Hindawi 2021-01-12 /pmc/articles/PMC7815417/ /pubmed/33506004 http://dx.doi.org/10.1155/2021/8180742 Text en Copyright © 2021 Arghavan Fatahi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Fatahi, Arghavan
Soleimani, Neda
Afrough, Parviz
Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment
title Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment
title_full Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment
title_fullStr Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment
title_full_unstemmed Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment
title_short Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment
title_sort anticancer activity of kefir on glioblastoma cancer cell as a new treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815417/
https://www.ncbi.nlm.nih.gov/pubmed/33506004
http://dx.doi.org/10.1155/2021/8180742
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