Cargando…

Predictive role of microsatellite instability for of PD-1 blockade in patients with advanced gastric cancer: a meta-analysis of randomized clinical trials

BACKGROUND: Several post hoc analyses of randomized controlled trials (RCTs) suggested the importance of microsatellite instability (MSI) as a positive predictive factor to immunotherapy in patients with advanced gastric cancer (GC); however, individually these have low statistical power. METHODS: R...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pietrantonio, F., Randon, G., Di Bartolomeo, M., Luciani, A., Chao, J., Smyth, E.C., Petrelli, F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815473/ https://www.ncbi.nlm.nih.gov/pubmed/33460964 http://dx.doi.org/10.1016/j.esmoop.2020.100036

Ejemplares similares

Efficacy and activity of PD-1 blockade in patients with advanced esophageal squamous cell carcinoma: a systematic review and meta-analysis with focus on the value of PD-L1 combined positive score
por: Leone, A.G., et al.
Publicado: (2022)

Outcomes and a prognostic classifier in patients with microsatellite instability-high metastatic gastric cancer receiving PD-1 blockade
por: Randon, Giovanni, et al.
Publicado: (2023)

The degree of microsatellite instability predicts response to PD-1 blockade immunotherapy in mismatch repair-deficient/microsatellite instability-high colorectal cancers
por: Wang, Qiao-Xuan, et al.
Publicado: (2021)

PD-1 blockade in neoadjuvant setting of DNA mismatch repair-deficient/microsatellite instability-high colorectal cancer
por: Liu, Ding-Xin, et al.
Publicado: (2020)

Implication of microsatellite instability in human gastric cancers
por: Shokal, Upasana, et al.
Publicado: (2012)

Microsatellite Instability in Korean Patients with Gastric Adenocarcinoma
por: Jee, Mi Seon, et al.
Publicado: (1997)

Prognostic impact of microsatellite instability in gastric cancer
por: Zepeda-Najar, Cesar, et al.
Publicado: (2021)

Editorial: Microsatellite and microsatellite instability
por: How-Kit, Alexandre, et al.
Publicado: (2023)

Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer
por: Bae, Yoon Sung, et al.
Publicado: (2015)

Adjuvant Chemotherapy in Microsatellite Instability–High Gastric Cancer
por: Kim, Jin Won, et al.
Publicado: (2020)

Clinical Implications of Microsatellite Instability in Early Gastric Cancer
por: Kim, Dong Gyu, et al.
Publicado: (2019)

Plasma-based microsatellite instability detection strategy to guide immune checkpoint blockade treatment
por: Wang, Zhenghang, et al.
Publicado: (2020)

Complete Response of High Microsatellite Instability Gastric Cancer and Synchronous Microsatellite Stability Rectal Cancer
por: Hunzeker, Zachary E, et al.
Publicado: (2022)

Microsatellite instability in colorectal cancer
por: Gian, Luigi de’Angelis, et al.
Publicado: (2018)

Elevated microsatellite instability at selected tetranucleotide (EMAST) repeats in gastric cancer: a distinct microsatellite instability type with potential clinical impact?
por: Herz, Anna‐Lina, et al.
Publicado: (2022)

Infrequent microsatellite instability in oesophageal cancers.
por: Muzeau, F., et al.
Publicado: (1997)

Chemotherapy or Targeted Therapy as Second-Line Treatment of Advanced Gastric Cancer. A Systematic Review and Meta-Analysis of Published Studies
por: Iacovelli, Roberto, et al.
Publicado: (2014)

Prognostic perspectives of PD-L1 combined with tumor-infiltrating lymphocytes, Epstein-Barr virus, and microsatellite instability in gastric carcinomas
por: Choi, Euno, et al.
Publicado: (2020)

Survival benefit with adjuvant chemotherapy in stage III microsatellite-high/deficient mismatch repair colon cancer: a systematic review and meta-analysis
por: Tomasello, Gianluca, et al.
Publicado: (2022)

Microsatellite Instability Is Associated with the Clinicopathologic Features of Gastric Cancer in Sporadic Gastric Cancer Patients
por: Kim, Shin Hyuk, et al.
Publicado: (2010)

Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms
por: Kim, Young Beak, et al.
Publicado: (2016)

Frequent Microsatellite Instabilities and Analyses of the Related Genes in Familial Gastric Cancers
por: Akiyama, Yoshimitsu, et al.
Publicado: (1996)

Prognostic significance of microsatellite instability-associated pathways and genes in gastric cancer
por: Hang, Xiaosheng, et al.
Publicado: (2018)

H. pylori infection is related to mitochondrial microsatellite instability in gastric carcinogenesis
por: Ling, Xianlong, et al.
Publicado: (2016)

Gastric adenocarcinoma with high‑level microsatellite instability: A case report
por: Alfaro, Alejandro, et al.
Publicado: (2023)

High Frequency of Microsatellite Instability among Non-Metastatic Gastric Cancer
por: Fanaei, Khadijeh, et al.
Publicado: (2022)

Towards Multiomics-Based Dissection of Anti-EGFR Sensitivity in Colorectal Cancer
por: Randon, Giovanni, et al.
Publicado: (2023)

Dual-layer spectral-detector CT for predicting microsatellite instability status and prognosis in locally advanced gastric cancer
por: Zhu, Yongjian, et al.
Publicado: (2023)

Combined prognostic effect of PD-L1 expression and immunoscore in microsatellite-unstable advanced gastric cancers
por: Kim, Kyung-Ju, et al.
Publicado: (2017)

Microsatellite instability in ovarian neoplasms.
por: King, B. L., et al.
Publicado: (1995)

Microsatellite instability in colorectal cancer
por: Horvat, Matej, et al.
Publicado: (2011)

Microsatellite instability in colorectal cancer
por: Nojadeh, Jafar Nouri, et al.
Publicado: (2018)

PD-L1 Expression Is Significantly Associated with Tumor Mutation Burden and Microsatellite Instability Score
por: Cho, Yoon Ah, et al.
Publicado: (2021)

Expression of hMLH1 is inactivated in the gastric adenomas with enhanced microsatellite instability
por: Baek, M J, et al.
Publicado: (2001)

HER-2/neu and E-cadherin Expression and Microsatellite Instability in Gastric Dysplasia
por: Ahmadi, L, et al.
Publicado: (2011)

High Frequency of Microsatellite Instability in Intestinal-type Gastric Cancer in Korean Patients
por: Choe, Won Hyuk, et al.
Publicado: (2005)

Clinicopathological and molecular alterations in early gastric cancers with the microsatellite instability‐high phenotype
por: Sugimoto, Ryo, et al.
Publicado: (2015)

Clinicopathologic Characteristics of Microsatellite Instable Gastric Carcinomas Revisited: Urgent Need for Standardization
por: Mathiak, Micaela, et al.
Publicado: (2017)

Microsatellite Instability and Altered Expressions of MLH1 and MSH2 in Gastric Cancer
por: Haron, Nor Hasyimah, et al.
Publicado: (2019)

Her2-Positive and Microsatellite Instability Status in Gastric Cancer—Clinicopathological Implications
por: Bermúdez, Ana, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_slgaqf290jdnb82s9kevgopgho