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Reactive oxygen species induce Cys106-mediated anti-parallel HMGB1 dimerization that protects against DNA damage

Oxidative stress can induce covalent disulfide bond formation between protein-protein thiol groups and generate hydroxyl free radicals that damage DNA. HMGB1 is a DNA chaperone and damage-associated molecular pattern molecule. As a redox-sensitive protein, HMGB1 contains three cysteine residues: Cys...

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Detalles Bibliográficos
Autores principales:	Kwak, Man Sup, Rhee, Woo Joong, Lee, Yong Joon, Kim, Hee Sue, Kim, Young Hun, Kwon, Min Kyung, Shin, Jeon-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815493/ https://www.ncbi.nlm.nih.gov/pubmed/33461096 http://dx.doi.org/10.1016/j.redox.2021.101858

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