Cargando…

Opioids drive breast cancer metastasis through the δ-opioid receptor and oncogenic STAT3

The opioid crisis of pain medication bears risks from addiction to cancer progression, but little experimental evidence exists. Expression of δ-opioid receptors (DORs) correlates with poor prognosis for breast cancer patients, but mechanistic insights into oncogenic signaling mechanisms of opioid-tr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tripolt, Sabrina, Neubauer, Heidi A., Knab, Vanessa M., Elmer, Dominik P., Aberger, Fritz, Moriggl, Richard, Fux, Daniela A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2021
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815495/ https://www.ncbi.nlm.nih.gov/pubmed/33465556 http://dx.doi.org/10.1016/j.neo.2020.12.011

Ejemplares similares

δ-opioid Receptor, Microglia and Neuroinflammation
por: Xu, Yuan, et al.
Publicado: (2023)

Opioids: Modulators of angiogenesis in wound healing and cancer
por: Ondrovics, Martina, et al.
Publicado: (2017)

Activation profiles of opioid ligands in HEK cells expressing δ opioid receptors
por: Gharagozlou, Parham, et al.
Publicado: (2002)

Clinical opioids differentially induce co-internalization of μ- and δ-opioid receptors
por: Bao, Fenghua, et al.
Publicado: (2018)

Reduction of Neuroinflammation by δ-Opioids Via STAT3-Dependent Pathway in Chronic Glaucoma Model
por: Husain, Shahid, et al.
Publicado: (2021)

Structure of the δ-opioid receptor bound to naltrindole
por: Granier, Sébastien, et al.
Publicado: (2012)

Neuropsychological Functions of μ- and δ-Opioid Systems
por: Polunina, Anna G., et al.
Publicado: (2013)

Are Prescription Opioids Driving the Opioid Crisis? Assumptions vs Facts
por: Rose, Mark Edmund
Publicado: (2018)

Opioid Receptor-Mediated and Non-Opioid Receptor-Mediated Roles of Opioids in Tumour Growth and Metastasis
por: Scroope, Claudia A., et al.
Publicado: (2021)

Hair Growth Promotion by δ-Opioid Receptor Activation
por: Zheng, Mei, et al.
Publicado: (2021)

Paroxetine Increases δ Opioid Responsiveness in Sensory Neurons
por: Brackley, Allison Doyle, et al.
Publicado: (2022)

Structural basis for bifunctional peptide recognition at human δ-Opioid receptor
por: Fenalti, Gustavo, et al.
Publicado: (2015)

Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway
por: Miyano, Kanako, et al.
Publicado: (2021)

Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation()
por: Schütz, Alexander, et al.
Publicado: (2015)

Development of a Bioavailable μ Opioid Receptor (MOPr) Agonist, δ Opioid Receptor (DOPr) Antagonist Peptide That Evokes Antinociception without Development of Acute Tolerance
por: Mosberg, Henry I., et al.
Publicado: (2014)

Opioid and Polydrug Use Among Patients in Opioid Maintenance Treatment
por: Carlsen, Siv-Elin Leirvaag, et al.
Publicado: (2020)

Antidepressant-like Effects of δ Opioid Receptor Agonists in Animal Models
por: Saitoh, Akiyoshi, et al.
Publicado: (2012)

Inhibition of Activity of GABA Transporter GAT1 by δ-Opioid Receptor
por: Pu, Lu, et al.
Publicado: (2012)

Exploring Binding Properties of Agonists Interacting with a δ-Opioid Receptor
por: Collu, Francesca, et al.
Publicado: (2012)

δ-Opioid Receptors, microRNAs, and Neuroinflammation in Cerebral Ischemia/Hypoxia
por: Chen, Yi-Meng, et al.
Publicado: (2020)

δ-Opioid receptor as a potential therapeutic target for ischemic stroke
por: Subedi, Kalpana, et al.
Publicado: (2019)

Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors
por: Pereira, Vanessa, et al.
Publicado: (2018)

Pharmacological Inhibition of Oncogenic STAT3 and STAT5 Signaling in Hematopoietic Cancers
por: Brachet-Botineau, Marie, et al.
Publicado: (2020)

Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy
por: Aberger, Fritz, et al.
Publicado: (2014)

Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Ligands
por: Harland, Aubrie A., et al.
Publicado: (2016)

Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors
por: Puls, Kristina, et al.
Publicado: (2022)

δ-Opioid receptor activation attenuates oxidative injury in the ischemic rat brain
por: Yang, Yilin, et al.
Publicado: (2009)

Regulation of Nitric Oxide Production by δ-Opioid Receptors during Glaucomatous Injury
por: Husain, Shahid, et al.
Publicado: (2014)

δ-Opioid Receptor Activation and MicroRNA Expression of the Rat Cortex in Hypoxia
por: Yang, Yilin, et al.
Publicado: (2012)

Prolonged morphine treatment alters δ opioid receptor post-internalization trafficking
por: Ong, E W, et al.
Publicado: (2015)

Histone Deacetylases Regulation by δ-Opioids in Human Optic Nerve Head Astrocytes
por: Zaidi, Syed A. H., et al.
Publicado: (2020)

Driving and legal status of Spanish opioid-dependent patients
por: Roncero, Carlos, et al.
Publicado: (2013)

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer
por: Wingelhofer, Bettina, et al.
Publicado: (2018)

STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway
por: Swoboda, Alexander, et al.
Publicado: (2021)

Abuse Potential and Pharmacodynamic Characteristics of Oral and Intranasal Eluxadoline, a Mixed μ- and κ-Opioid Receptor Agonist and δ-Opioid Receptor Antagonist
por: Levy-Cooperman, N., et al.
Publicado: (2016)

The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth
por: Nivarthi, Harini, et al.
Publicado: (2016)

Direct Targeting Options for STAT3 and STAT5 in Cancer
por: Orlova, Anna, et al.
Publicado: (2019)

From inflammation to gastric cancer – the importance of Hedgehog/GLI signaling in Helicobacter pylori-induced chronic inflammatory and neoplastic diseases
por: Wessler, Silja, et al.
Publicado: (2017)

Opioids, opioids, opioids: The plague among middle-aged white Americans
por: Hellman, Matilda
Publicado: (2018)

Correction: The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth
por: Nivarthi, Harini, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pfqro9t0on47554odsckkb534e