Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a chronic glomerular disease with poor clinical outcomes. Podocyte loss via apoptosis is one important mechanism underlying the pathogenesis of FSGS. Recently, Yes-associated-protein (YAP), a key downstream protein in the Hippo pathway, was identified as...

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Detalles Bibliográficos
Autores principales: Zhuang, Qiyuan, Li, Fang, Liu, Jun, Wang, Hongyu, Tian, Yuchen, Zhang, Zhigang, Wang, Feng, Zhao, Zhonghua, Chen, Jianchun, Wu, Huijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815513/
https://www.ncbi.nlm.nih.gov/pubmed/33203894
http://dx.doi.org/10.1038/s41374-020-00503-3

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