Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis

While the significance of acquired genetic abnormalities in the initiation of hepatocellular carcinoma (HCC) has been established, the role of epigenetic modification remains unknown. Here we identified the pivotal role of histone methyltransferase G9a in the DNA damage-triggered initiation of HCC....

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Detalles Bibliográficos
Autores principales: Nakatsuka, Takuma, Tateishi, Keisuke, Kato, Hiroyuki, Fujiwara, Hiroaki, Yamamoto, Keisuke, Kudo, Yotaro, Nakagawa, Hayato, Tanaka, Yasuo, Ijichi, Hideaki, Ikenoue, Tsuneo, Ishizawa, Takeaki, Hasegawa, Kiyoshi, Tachibana, Makoto, Shinkai, Yoichi, Koike, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815717/
https://www.ncbi.nlm.nih.gov/pubmed/33468997
http://dx.doi.org/10.1038/s41419-020-03381-1

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