Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

The main challenges for programmed cell death 1(PD-1)/PD-1 ligand (PD-L1) checkpoint blockade lie in a lack of sufficient T cell infiltration, tumor immunosuppressive microenvironment, and the inadequate tumor accumulation and penetration of anti-PD-1/PD-L1 antibody. Resetting tumor-associated macro...

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Detalles Bibliográficos
Autores principales: Wei, Zhaohan, Zhang, Xiaoqiong, Yong, Tuying, Bie, Nana, Zhan, Guiting, Li, Xin, Liang, Qingle, Li, Jianye, Yu, Jingjing, Huang, Gang, Yan, Yuchen, Zhang, Zelong, Zhang, Bixiang, Gan, Lu, Huang, Bo, Yang, Xiangliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815730/
https://www.ncbi.nlm.nih.gov/pubmed/33469052
http://dx.doi.org/10.1038/s41467-020-20723-x

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