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Identifying threshold sizes for enlarged abdominal lymph nodes in different age ranges from about 200,000 individual’s data

The threshold size for enlarged abdominal lymph nodes (E-ALNs), a common pediatric disorder, has yet to be standardized. According to the maximum short-axis diameter, this study divided ALNs into Grade A (≥ 10 mm), Grade B (8–10 mm), Grade C (5–8 mm), and Grade D (< 5 mm, normal). To identify the...

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Autores principales: He, Lili, Sun, Yinghua, Huang, Guoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815733/
https://www.ncbi.nlm.nih.gov/pubmed/33469140
http://dx.doi.org/10.1038/s41598-021-81339-9
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author He, Lili
Sun, Yinghua
Huang, Guoying
author_facet He, Lili
Sun, Yinghua
Huang, Guoying
author_sort He, Lili
collection PubMed
description The threshold size for enlarged abdominal lymph nodes (E-ALNs), a common pediatric disorder, has yet to be standardized. According to the maximum short-axis diameter, this study divided ALNs into Grade A (≥ 10 mm), Grade B (8–10 mm), Grade C (5–8 mm), and Grade D (< 5 mm, normal). To identify the threshold size for E-ALNs, the prevalence of each grade was compared between asymptomatic individuals and symptomatic (e.g., abdominal pain) individuals without other diseases (e.g., appendicitis) that could explain the symptoms for different ages using data from > 200,000 individuals. The results showed the following: (1) For ages 1–3 years, the recommended threshold size is 8 mm, as the differences in the prevalence between the two groups were nonsignificant for Grade C but significant (p < 0.05) for both Grades A and B. (2) For ages 3–14 years, the recommended threshold size is 5 mm, as the differences between the two groups were significant (p < 0.05) for Grades A, B, and C. (3) The prevalence of Grades A, B, and C was very low for ages 0–1 years and high for ages 1–6 years. (4) The prevalence for males was generally higher than that for females for Grades A and B.
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spelling pubmed-78157332021-01-21 Identifying threshold sizes for enlarged abdominal lymph nodes in different age ranges from about 200,000 individual’s data He, Lili Sun, Yinghua Huang, Guoying Sci Rep Article The threshold size for enlarged abdominal lymph nodes (E-ALNs), a common pediatric disorder, has yet to be standardized. According to the maximum short-axis diameter, this study divided ALNs into Grade A (≥ 10 mm), Grade B (8–10 mm), Grade C (5–8 mm), and Grade D (< 5 mm, normal). To identify the threshold size for E-ALNs, the prevalence of each grade was compared between asymptomatic individuals and symptomatic (e.g., abdominal pain) individuals without other diseases (e.g., appendicitis) that could explain the symptoms for different ages using data from > 200,000 individuals. The results showed the following: (1) For ages 1–3 years, the recommended threshold size is 8 mm, as the differences in the prevalence between the two groups were nonsignificant for Grade C but significant (p < 0.05) for both Grades A and B. (2) For ages 3–14 years, the recommended threshold size is 5 mm, as the differences between the two groups were significant (p < 0.05) for Grades A, B, and C. (3) The prevalence of Grades A, B, and C was very low for ages 0–1 years and high for ages 1–6 years. (4) The prevalence for males was generally higher than that for females for Grades A and B. Nature Publishing Group UK 2021-01-19 /pmc/articles/PMC7815733/ /pubmed/33469140 http://dx.doi.org/10.1038/s41598-021-81339-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
He, Lili
Sun, Yinghua
Huang, Guoying
Identifying threshold sizes for enlarged abdominal lymph nodes in different age ranges from about 200,000 individual’s data
title Identifying threshold sizes for enlarged abdominal lymph nodes in different age ranges from about 200,000 individual’s data
title_full Identifying threshold sizes for enlarged abdominal lymph nodes in different age ranges from about 200,000 individual’s data
title_fullStr Identifying threshold sizes for enlarged abdominal lymph nodes in different age ranges from about 200,000 individual’s data
title_full_unstemmed Identifying threshold sizes for enlarged abdominal lymph nodes in different age ranges from about 200,000 individual’s data
title_short Identifying threshold sizes for enlarged abdominal lymph nodes in different age ranges from about 200,000 individual’s data
title_sort identifying threshold sizes for enlarged abdominal lymph nodes in different age ranges from about 200,000 individual’s data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815733/
https://www.ncbi.nlm.nih.gov/pubmed/33469140
http://dx.doi.org/10.1038/s41598-021-81339-9
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