Cargando…
Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies
Hematopoiesis requires finely tuned regulation of gene expression at each stage of development. The regulation of gene transcription involves not only individual transcription factors (TFs) but also transcription complexes (TCs) composed of transcription factor(s) and multisubunit cofactors. In thei...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815747/ https://www.ncbi.nlm.nih.gov/pubmed/33468999 http://dx.doi.org/10.1038/s41392-020-00422-1 |
_version_ | 1783638297635979264 |
---|---|
author | Wang, Zi Wang, Pan Li, Yanan Peng, Hongling Zhu, Yu Mohandas, Narla Liu, Jing |
author_facet | Wang, Zi Wang, Pan Li, Yanan Peng, Hongling Zhu, Yu Mohandas, Narla Liu, Jing |
author_sort | Wang, Zi |
collection | PubMed |
description | Hematopoiesis requires finely tuned regulation of gene expression at each stage of development. The regulation of gene transcription involves not only individual transcription factors (TFs) but also transcription complexes (TCs) composed of transcription factor(s) and multisubunit cofactors. In their normal compositions, TCs orchestrate lineage-specific patterns of gene expression and ensure the production of the correct proportions of individual cell lineages during hematopoiesis. The integration of posttranslational and conformational modifications in the chromatin landscape, nucleosomes, histones and interacting components via the cofactor–TF interplay is critical to optimal TF activity. Mutations or translocations of cofactor genes are expected to alter cofactor–TF interactions, which may be causative for the pathogenesis of various hematologic disorders. Blocking TF oncogenic activity in hematologic disorders through targeting cofactors in aberrant complexes has been an exciting therapeutic strategy. In this review, we summarize the current knowledge regarding the models and functions of cofactor–TF interplay in physiological hematopoiesis and highlight their implications in the etiology of hematological malignancies. This review presents a deep insight into the physiological and pathological implications of transcription machinery in the blood system. |
format | Online Article Text |
id | pubmed-7815747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78157472021-01-28 Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies Wang, Zi Wang, Pan Li, Yanan Peng, Hongling Zhu, Yu Mohandas, Narla Liu, Jing Signal Transduct Target Ther Review Article Hematopoiesis requires finely tuned regulation of gene expression at each stage of development. The regulation of gene transcription involves not only individual transcription factors (TFs) but also transcription complexes (TCs) composed of transcription factor(s) and multisubunit cofactors. In their normal compositions, TCs orchestrate lineage-specific patterns of gene expression and ensure the production of the correct proportions of individual cell lineages during hematopoiesis. The integration of posttranslational and conformational modifications in the chromatin landscape, nucleosomes, histones and interacting components via the cofactor–TF interplay is critical to optimal TF activity. Mutations or translocations of cofactor genes are expected to alter cofactor–TF interactions, which may be causative for the pathogenesis of various hematologic disorders. Blocking TF oncogenic activity in hematologic disorders through targeting cofactors in aberrant complexes has been an exciting therapeutic strategy. In this review, we summarize the current knowledge regarding the models and functions of cofactor–TF interplay in physiological hematopoiesis and highlight their implications in the etiology of hematological malignancies. This review presents a deep insight into the physiological and pathological implications of transcription machinery in the blood system. Nature Publishing Group UK 2021-01-20 /pmc/articles/PMC7815747/ /pubmed/33468999 http://dx.doi.org/10.1038/s41392-020-00422-1 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Wang, Zi Wang, Pan Li, Yanan Peng, Hongling Zhu, Yu Mohandas, Narla Liu, Jing Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies |
title | Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies |
title_full | Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies |
title_fullStr | Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies |
title_full_unstemmed | Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies |
title_short | Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies |
title_sort | interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815747/ https://www.ncbi.nlm.nih.gov/pubmed/33468999 http://dx.doi.org/10.1038/s41392-020-00422-1 |
work_keys_str_mv | AT wangzi interplaybetweencofactorsandtranscriptionfactorsinhematopoiesisandhematologicalmalignancies AT wangpan interplaybetweencofactorsandtranscriptionfactorsinhematopoiesisandhematologicalmalignancies AT liyanan interplaybetweencofactorsandtranscriptionfactorsinhematopoiesisandhematologicalmalignancies AT penghongling interplaybetweencofactorsandtranscriptionfactorsinhematopoiesisandhematologicalmalignancies AT zhuyu interplaybetweencofactorsandtranscriptionfactorsinhematopoiesisandhematologicalmalignancies AT mohandasnarla interplaybetweencofactorsandtranscriptionfactorsinhematopoiesisandhematologicalmalignancies AT liujing interplaybetweencofactorsandtranscriptionfactorsinhematopoiesisandhematologicalmalignancies |