Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated

We found ADAM8 enzymatic activity elevated in degenerative human intervertebral disc (IVD). Here, we examined the discs in ADAM8-inactivation mice that carry a mutation preventing self-activation of the enzyme. Surprisingly, elevated gene expression for inflammatory markers (Cxcl1, IL6) was observed...

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Detalles Bibliográficos
Autores principales: Zhang, Yejia, Tian, Zuozhen, Gerard, David, Yao, Lutian, Shofer, Frances S., Cs-Szabo, Gabriella, Qin, Ling, Pacifici, Maurizio, Enomoto-Iwamoto, Motomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815795/
https://www.ncbi.nlm.nih.gov/pubmed/33469101
http://dx.doi.org/10.1038/s41598-021-81495-y

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