Cargando…

Gray matter structural networks related to (18)F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients

OBJECTIVE: This study aimed to examine the alterations in gray matter networks related to tau retention in Alzheimer's disease (AD) patients and cognitively normal (CN) older individuals. METHODS: Eighteen amyloid-positive AD patients and 30 age- and sex-matched amyloid-negative CN controls wer...

Descripción completa

Detalles Bibliográficos
Autores principales: Shigemoto, Yoko, Sone, Daichi, Okita, Kyoji, Maikusa, Norihide, Yamao, Tensho, Kimura, Yukio, Suzuki, Fumio, Fujii, Hiroyuki, Kato, Koichi, Sato, Noriko, Matsuda, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815816/
https://www.ncbi.nlm.nih.gov/pubmed/33511292
http://dx.doi.org/10.1016/j.ensci.2021.100309
_version_ 1783638313280733184
author Shigemoto, Yoko
Sone, Daichi
Okita, Kyoji
Maikusa, Norihide
Yamao, Tensho
Kimura, Yukio
Suzuki, Fumio
Fujii, Hiroyuki
Kato, Koichi
Sato, Noriko
Matsuda, Hiroshi
author_facet Shigemoto, Yoko
Sone, Daichi
Okita, Kyoji
Maikusa, Norihide
Yamao, Tensho
Kimura, Yukio
Suzuki, Fumio
Fujii, Hiroyuki
Kato, Koichi
Sato, Noriko
Matsuda, Hiroshi
author_sort Shigemoto, Yoko
collection PubMed
description OBJECTIVE: This study aimed to examine the alterations in gray matter networks related to tau retention in Alzheimer's disease (AD) patients and cognitively normal (CN) older individuals. METHODS: Eighteen amyloid-positive AD patients and 30 age- and sex-matched amyloid-negative CN controls were enrolled. All underwent 3D T1-weighted MRI, amyloid positron-emission tomography imaging (PET) with (11)C-Pittsburgh Compound B (PiB), and tau PET with (18)F-THK5351. The structural networks extracted from the T1-weighted MRI data based on cortical similarities within single subjects were analyzed. Based on graph theoretical approach, global and local network properties across the whole brain were computed. Group comparisons of global and local network properties were evaluated between the groups. Then, we correlated the global and local network measures with total cerebral (18)F-THK5351 retention. RESULTS: AD patients moved toward more randomized global network compared to controls and regional differences were observed in the default mode network (DMN) area. No significant correlations existed between global network properties and tau retention. On a local level, AD and controls showed opposite relationships between network properties and tau retention mainly in the DMN areas; CN controls showed positive correlations, whereas AD showed negative correlations. CONCLUSION: We found opposite relationships between local network properties and tau retention between amyloid-positive AD patients and amyloid-negative controls. Our findings suggest that the presence of amyloid and induced exacerbated tau retention alter the relationship of local network properties and tau retention.
format Online
Article
Text
id pubmed-7815816
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-78158162021-01-27 Gray matter structural networks related to (18)F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients Shigemoto, Yoko Sone, Daichi Okita, Kyoji Maikusa, Norihide Yamao, Tensho Kimura, Yukio Suzuki, Fumio Fujii, Hiroyuki Kato, Koichi Sato, Noriko Matsuda, Hiroshi eNeurologicalSci Original Article OBJECTIVE: This study aimed to examine the alterations in gray matter networks related to tau retention in Alzheimer's disease (AD) patients and cognitively normal (CN) older individuals. METHODS: Eighteen amyloid-positive AD patients and 30 age- and sex-matched amyloid-negative CN controls were enrolled. All underwent 3D T1-weighted MRI, amyloid positron-emission tomography imaging (PET) with (11)C-Pittsburgh Compound B (PiB), and tau PET with (18)F-THK5351. The structural networks extracted from the T1-weighted MRI data based on cortical similarities within single subjects were analyzed. Based on graph theoretical approach, global and local network properties across the whole brain were computed. Group comparisons of global and local network properties were evaluated between the groups. Then, we correlated the global and local network measures with total cerebral (18)F-THK5351 retention. RESULTS: AD patients moved toward more randomized global network compared to controls and regional differences were observed in the default mode network (DMN) area. No significant correlations existed between global network properties and tau retention. On a local level, AD and controls showed opposite relationships between network properties and tau retention mainly in the DMN areas; CN controls showed positive correlations, whereas AD showed negative correlations. CONCLUSION: We found opposite relationships between local network properties and tau retention between amyloid-positive AD patients and amyloid-negative controls. Our findings suggest that the presence of amyloid and induced exacerbated tau retention alter the relationship of local network properties and tau retention. Elsevier 2021-01-07 /pmc/articles/PMC7815816/ /pubmed/33511292 http://dx.doi.org/10.1016/j.ensci.2021.100309 Text en © 2021 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Shigemoto, Yoko
Sone, Daichi
Okita, Kyoji
Maikusa, Norihide
Yamao, Tensho
Kimura, Yukio
Suzuki, Fumio
Fujii, Hiroyuki
Kato, Koichi
Sato, Noriko
Matsuda, Hiroshi
Gray matter structural networks related to (18)F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients
title Gray matter structural networks related to (18)F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients
title_full Gray matter structural networks related to (18)F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients
title_fullStr Gray matter structural networks related to (18)F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients
title_full_unstemmed Gray matter structural networks related to (18)F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients
title_short Gray matter structural networks related to (18)F-THK5351 retention in cognitively normal older adults and Alzheimer's disease patients
title_sort gray matter structural networks related to (18)f-thk5351 retention in cognitively normal older adults and alzheimer's disease patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815816/
https://www.ncbi.nlm.nih.gov/pubmed/33511292
http://dx.doi.org/10.1016/j.ensci.2021.100309
work_keys_str_mv AT shigemotoyoko graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients
AT sonedaichi graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients
AT okitakyoji graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients
AT maikusanorihide graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients
AT yamaotensho graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients
AT kimurayukio graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients
AT suzukifumio graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients
AT fujiihiroyuki graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients
AT katokoichi graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients
AT satonoriko graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients
AT matsudahiroshi graymatterstructuralnetworksrelatedto18fthk5351retentionincognitivelynormalolderadultsandalzheimersdiseasepatients