Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy

From February to April 2020, Lombardy (Italy) reported the highest numbers of SARS-CoV-2 cases worldwide. By analyzing 346 whole SARS-CoV-2 genomes, we demonstrate the presence of seven viral lineages in Lombardy, frequently sustained by local transmission chains and at least two likely to have orig...

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Detalles Bibliográficos
Autores principales: Alteri, Claudia, Cento, Valeria, Piralla, Antonio, Costabile, Valentino, Tallarita, Monica, Colagrossi, Luna, Renica, Silvia, Giardina, Federica, Novazzi, Federica, Gaiarsa, Stefano, Matarazzo, Elisa, Antonello, Maria, Vismara, Chiara, Fumagalli, Roberto, Epis, Oscar Massimiliano, Puoti, Massimo, Perno, Carlo Federico, Baldanti, Fausto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815831/
https://www.ncbi.nlm.nih.gov/pubmed/33469026
http://dx.doi.org/10.1038/s41467-020-20688-x
Descripción
Sumario:From February to April 2020, Lombardy (Italy) reported the highest numbers of SARS-CoV-2 cases worldwide. By analyzing 346 whole SARS-CoV-2 genomes, we demonstrate the presence of seven viral lineages in Lombardy, frequently sustained by local transmission chains and at least two likely to have originated in Italy. Six single nucleotide polymorphisms (five of them non-synonymous) characterized the SARS-CoV-2 sequences, none of them affecting N-glycosylation sites. The seven lineages, and the presence of local transmission clusters within three of them, revealed that sustained community transmission was underway before the first COVID-19 case had been detected in Lombardy.

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