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Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy
From February to April 2020, Lombardy (Italy) reported the highest numbers of SARS-CoV-2 cases worldwide. By analyzing 346 whole SARS-CoV-2 genomes, we demonstrate the presence of seven viral lineages in Lombardy, frequently sustained by local transmission chains and at least two likely to have orig...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815831/ https://www.ncbi.nlm.nih.gov/pubmed/33469026 http://dx.doi.org/10.1038/s41467-020-20688-x |
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| author | Alteri, Claudia Cento, Valeria Piralla, Antonio Costabile, Valentino Tallarita, Monica Colagrossi, Luna Renica, Silvia Giardina, Federica Novazzi, Federica Gaiarsa, Stefano Matarazzo, Elisa Antonello, Maria Vismara, Chiara Fumagalli, Roberto Epis, Oscar Massimiliano Puoti, Massimo Perno, Carlo Federico Baldanti, Fausto |
| author_facet | Alteri, Claudia Cento, Valeria Piralla, Antonio Costabile, Valentino Tallarita, Monica Colagrossi, Luna Renica, Silvia Giardina, Federica Novazzi, Federica Gaiarsa, Stefano Matarazzo, Elisa Antonello, Maria Vismara, Chiara Fumagalli, Roberto Epis, Oscar Massimiliano Puoti, Massimo Perno, Carlo Federico Baldanti, Fausto |
| author_sort | Alteri, Claudia |
| collection | PubMed |
| description | From February to April 2020, Lombardy (Italy) reported the highest numbers of SARS-CoV-2 cases worldwide. By analyzing 346 whole SARS-CoV-2 genomes, we demonstrate the presence of seven viral lineages in Lombardy, frequently sustained by local transmission chains and at least two likely to have originated in Italy. Six single nucleotide polymorphisms (five of them non-synonymous) characterized the SARS-CoV-2 sequences, none of them affecting N-glycosylation sites. The seven lineages, and the presence of local transmission clusters within three of them, revealed that sustained community transmission was underway before the first COVID-19 case had been detected in Lombardy. |
| format | Online Article Text |
| id | pubmed-7815831 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-78158312021-01-28 Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy Alteri, Claudia Cento, Valeria Piralla, Antonio Costabile, Valentino Tallarita, Monica Colagrossi, Luna Renica, Silvia Giardina, Federica Novazzi, Federica Gaiarsa, Stefano Matarazzo, Elisa Antonello, Maria Vismara, Chiara Fumagalli, Roberto Epis, Oscar Massimiliano Puoti, Massimo Perno, Carlo Federico Baldanti, Fausto Nat Commun Article From February to April 2020, Lombardy (Italy) reported the highest numbers of SARS-CoV-2 cases worldwide. By analyzing 346 whole SARS-CoV-2 genomes, we demonstrate the presence of seven viral lineages in Lombardy, frequently sustained by local transmission chains and at least two likely to have originated in Italy. Six single nucleotide polymorphisms (five of them non-synonymous) characterized the SARS-CoV-2 sequences, none of them affecting N-glycosylation sites. The seven lineages, and the presence of local transmission clusters within three of them, revealed that sustained community transmission was underway before the first COVID-19 case had been detected in Lombardy. Nature Publishing Group UK 2021-01-19 /pmc/articles/PMC7815831/ /pubmed/33469026 http://dx.doi.org/10.1038/s41467-020-20688-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Alteri, Claudia Cento, Valeria Piralla, Antonio Costabile, Valentino Tallarita, Monica Colagrossi, Luna Renica, Silvia Giardina, Federica Novazzi, Federica Gaiarsa, Stefano Matarazzo, Elisa Antonello, Maria Vismara, Chiara Fumagalli, Roberto Epis, Oscar Massimiliano Puoti, Massimo Perno, Carlo Federico Baldanti, Fausto Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy |
| title | Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy |
| title_full | Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy |
| title_fullStr | Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy |
| title_full_unstemmed | Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy |
| title_short | Genomic epidemiology of SARS-CoV-2 reveals multiple lineages and early spread of SARS-CoV-2 infections in Lombardy, Italy |
| title_sort | genomic epidemiology of sars-cov-2 reveals multiple lineages and early spread of sars-cov-2 infections in lombardy, italy |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815831/ https://www.ncbi.nlm.nih.gov/pubmed/33469026 http://dx.doi.org/10.1038/s41467-020-20688-x |
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