Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD
Structural neuroimaging studies of posttraumatic stress disorder (PTSD) have typically reported reduced cortical thickness (CT) and gray matter volume (GMV) in subcortical structures and networks involved in memory retrieval, emotional processing and regulation, and fear acquisition and extinction....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815843/ https://www.ncbi.nlm.nih.gov/pubmed/33469080 http://dx.doi.org/10.1038/s41598-020-80776-2 |
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author | Crombie, Kevin M. Ross, Marisa C. Letkiewicz, Allison M. Sartin-Tarm, Anneliis Cisler, Josh M. |
author_facet | Crombie, Kevin M. Ross, Marisa C. Letkiewicz, Allison M. Sartin-Tarm, Anneliis Cisler, Josh M. |
author_sort | Crombie, Kevin M. |
collection | PubMed |
description | Structural neuroimaging studies of posttraumatic stress disorder (PTSD) have typically reported reduced cortical thickness (CT) and gray matter volume (GMV) in subcortical structures and networks involved in memory retrieval, emotional processing and regulation, and fear acquisition and extinction. Although PTSD is more common in women, and interpersonal violence (IPV) exposure is a more potent risk factor for developing PTSD relative to other forms of trauma, most of the existing literature examined combat-exposed men with PTSD. Vertex-wise CT and subcortical GMV analyses were conducted to examine potential differences in a large, well-characterized sample of women with PTSD stemming from IPV-exposure (n = 99) compared to healthy trauma-free women without a diagnosis of PTSD (n = 22). Subgroup analyses were also conducted to determine whether symptom severity within specific PTSD symptom clusters (e.g., re-experiencing, active avoidance, hyperarousal) predict CT and GMV after controlling for comorbid depression and anxiety. Results indicated that a diagnosis of PTSD in women with IPV-exposure did not significantly predict differences in CT across the cortex or GMV in the amygdala or hippocampus compared to healthy controls. However, within the PTSD group, greater re-experiencing symptom severity was associated with decreased CT in the left inferior and middle temporal gyrus, and decreased CT in the right parahippocampal and medial temporal gyrus. In contrast, greater active avoidance symptom severity was associated with greater CT in the left lateral fissure, postcentral gyrus, and middle/lateral occipital cortex, and greater CT in the right paracentral, posterior cingulate, and superior occipital gyrus. In terms of GMV, greater hyperarousal symptom severity was associated with reduced left amygdala GMV, while greater active avoidance symptom severity was associated with greater right amygdala GMV. These findings suggest that structural brain alterations among women with IPV-related PTSD may be driven by symptom severity within specific symptom clusters and that PTSD symptom clusters may have a differential (increased or decreased) association with brain structures. |
format | Online Article Text |
id | pubmed-7815843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78158432021-01-21 Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD Crombie, Kevin M. Ross, Marisa C. Letkiewicz, Allison M. Sartin-Tarm, Anneliis Cisler, Josh M. Sci Rep Article Structural neuroimaging studies of posttraumatic stress disorder (PTSD) have typically reported reduced cortical thickness (CT) and gray matter volume (GMV) in subcortical structures and networks involved in memory retrieval, emotional processing and regulation, and fear acquisition and extinction. Although PTSD is more common in women, and interpersonal violence (IPV) exposure is a more potent risk factor for developing PTSD relative to other forms of trauma, most of the existing literature examined combat-exposed men with PTSD. Vertex-wise CT and subcortical GMV analyses were conducted to examine potential differences in a large, well-characterized sample of women with PTSD stemming from IPV-exposure (n = 99) compared to healthy trauma-free women without a diagnosis of PTSD (n = 22). Subgroup analyses were also conducted to determine whether symptom severity within specific PTSD symptom clusters (e.g., re-experiencing, active avoidance, hyperarousal) predict CT and GMV after controlling for comorbid depression and anxiety. Results indicated that a diagnosis of PTSD in women with IPV-exposure did not significantly predict differences in CT across the cortex or GMV in the amygdala or hippocampus compared to healthy controls. However, within the PTSD group, greater re-experiencing symptom severity was associated with decreased CT in the left inferior and middle temporal gyrus, and decreased CT in the right parahippocampal and medial temporal gyrus. In contrast, greater active avoidance symptom severity was associated with greater CT in the left lateral fissure, postcentral gyrus, and middle/lateral occipital cortex, and greater CT in the right paracentral, posterior cingulate, and superior occipital gyrus. In terms of GMV, greater hyperarousal symptom severity was associated with reduced left amygdala GMV, while greater active avoidance symptom severity was associated with greater right amygdala GMV. These findings suggest that structural brain alterations among women with IPV-related PTSD may be driven by symptom severity within specific symptom clusters and that PTSD symptom clusters may have a differential (increased or decreased) association with brain structures. Nature Publishing Group UK 2021-01-19 /pmc/articles/PMC7815843/ /pubmed/33469080 http://dx.doi.org/10.1038/s41598-020-80776-2 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Crombie, Kevin M. Ross, Marisa C. Letkiewicz, Allison M. Sartin-Tarm, Anneliis Cisler, Josh M. Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD |
title | Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD |
title_full | Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD |
title_fullStr | Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD |
title_full_unstemmed | Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD |
title_short | Differential relationships of PTSD symptom clusters with cortical thickness and grey matter volumes among women with PTSD |
title_sort | differential relationships of ptsd symptom clusters with cortical thickness and grey matter volumes among women with ptsd |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815843/ https://www.ncbi.nlm.nih.gov/pubmed/33469080 http://dx.doi.org/10.1038/s41598-020-80776-2 |
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