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The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients
To explore the value, and influencing factors, of D-dimer on the prognosis of patients with COVID-19. A total of 1,114 patients with confirmed COVID-19 who were admitted to three designated COVID-19 hospitals in Wuhan, China from January 18, 2020, to March 24, 2020, were included in this study. We e...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815913/ https://www.ncbi.nlm.nih.gov/pubmed/33469072 http://dx.doi.org/10.1038/s41598-021-81300-w |
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author | He, Xiaokang Yao, Fei Chen, Jie Wang, Yan Fang, Xiangming Lin, Xuan Long, Hui Wang, Qiang Wu, Qingming |
author_facet | He, Xiaokang Yao, Fei Chen, Jie Wang, Yan Fang, Xiangming Lin, Xuan Long, Hui Wang, Qiang Wu, Qingming |
author_sort | He, Xiaokang |
collection | PubMed |
description | To explore the value, and influencing factors, of D-dimer on the prognosis of patients with COVID-19. A total of 1,114 patients with confirmed COVID-19 who were admitted to three designated COVID-19 hospitals in Wuhan, China from January 18, 2020, to March 24, 2020, were included in this study. We examined the relationship between peripheral blood levels of D-dimer, and clinical classification and prognosis, as well as its related influencing factors. D-dimer levels were found to be related to the clinical classification and the prognosis of clinical outcome. D-dimer levels were more likely to be abnormal in severely and critically ill patients compared with mild and ordinary cases, while D-dimer levels of patients who had died were significantly higher than those of surviving patients according to the results of the first and last lab tests. The results from ROC analyses for mortality risk showed that the AUCs of D-dimer were 0.909, YI was 0.765 at the last lab test, and a D-dimer value of 2.025 mg/L was regarded to be the optimal probability cutoff for a prognosis of death. In addition, we found that patients with advanced age, male gender, dyspnea symptoms, and some underlying diseases have a higher D-dimer value (p < 0.05). In short, D-dimer is related to the clinical classification and can be used to evaluate the prognosis of COVID-19 patients. The D-dimer value of 2.025 mg/L was the optimal probability cutoff for judging an outcome of death. Advanced age, male gender, dyspnea symptoms, and some underlying diseases are influencing factors for D-dimer levels, which impacts the prognosis of patients. |
format | Online Article Text |
id | pubmed-7815913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78159132021-01-21 The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients He, Xiaokang Yao, Fei Chen, Jie Wang, Yan Fang, Xiangming Lin, Xuan Long, Hui Wang, Qiang Wu, Qingming Sci Rep Article To explore the value, and influencing factors, of D-dimer on the prognosis of patients with COVID-19. A total of 1,114 patients with confirmed COVID-19 who were admitted to three designated COVID-19 hospitals in Wuhan, China from January 18, 2020, to March 24, 2020, were included in this study. We examined the relationship between peripheral blood levels of D-dimer, and clinical classification and prognosis, as well as its related influencing factors. D-dimer levels were found to be related to the clinical classification and the prognosis of clinical outcome. D-dimer levels were more likely to be abnormal in severely and critically ill patients compared with mild and ordinary cases, while D-dimer levels of patients who had died were significantly higher than those of surviving patients according to the results of the first and last lab tests. The results from ROC analyses for mortality risk showed that the AUCs of D-dimer were 0.909, YI was 0.765 at the last lab test, and a D-dimer value of 2.025 mg/L was regarded to be the optimal probability cutoff for a prognosis of death. In addition, we found that patients with advanced age, male gender, dyspnea symptoms, and some underlying diseases have a higher D-dimer value (p < 0.05). In short, D-dimer is related to the clinical classification and can be used to evaluate the prognosis of COVID-19 patients. The D-dimer value of 2.025 mg/L was the optimal probability cutoff for judging an outcome of death. Advanced age, male gender, dyspnea symptoms, and some underlying diseases are influencing factors for D-dimer levels, which impacts the prognosis of patients. Nature Publishing Group UK 2021-01-19 /pmc/articles/PMC7815913/ /pubmed/33469072 http://dx.doi.org/10.1038/s41598-021-81300-w Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article He, Xiaokang Yao, Fei Chen, Jie Wang, Yan Fang, Xiangming Lin, Xuan Long, Hui Wang, Qiang Wu, Qingming The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients |
title | The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients |
title_full | The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients |
title_fullStr | The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients |
title_full_unstemmed | The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients |
title_short | The poor prognosis and influencing factors of high D-dimer levels for COVID-19 patients |
title_sort | poor prognosis and influencing factors of high d-dimer levels for covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815913/ https://www.ncbi.nlm.nih.gov/pubmed/33469072 http://dx.doi.org/10.1038/s41598-021-81300-w |
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