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White matter integrity in young medication-naïve bipolar II depressed adults

It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs w...

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Autores principales: Mak, Arthur Dun Ping, Leung, Owen Ngo Wang, Chou, Idy Wing Yi, Wong, Sheila Lok Yiu, Chu, Winnie Chiu-wing, Yeung, David, So, Suzanne Ho-wai, Ma, Suk Ling, Lam, Linda Chiu Wah, Leung, Chi Ming, Lee, Sing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815920/
https://www.ncbi.nlm.nih.gov/pubmed/33469064
http://dx.doi.org/10.1038/s41598-021-81355-9
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author Mak, Arthur Dun Ping
Leung, Owen Ngo Wang
Chou, Idy Wing Yi
Wong, Sheila Lok Yiu
Chu, Winnie Chiu-wing
Yeung, David
So, Suzanne Ho-wai
Ma, Suk Ling
Lam, Linda Chiu Wah
Leung, Chi Ming
Lee, Sing
author_facet Mak, Arthur Dun Ping
Leung, Owen Ngo Wang
Chou, Idy Wing Yi
Wong, Sheila Lok Yiu
Chu, Winnie Chiu-wing
Yeung, David
So, Suzanne Ho-wai
Ma, Suk Ling
Lam, Linda Chiu Wah
Leung, Chi Ming
Lee, Sing
author_sort Mak, Arthur Dun Ping
collection PubMed
description It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73–0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of [Formula: see text] : 0.00073, 5.22, ηp(2) = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters.
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spelling pubmed-78159202021-01-21 White matter integrity in young medication-naïve bipolar II depressed adults Mak, Arthur Dun Ping Leung, Owen Ngo Wang Chou, Idy Wing Yi Wong, Sheila Lok Yiu Chu, Winnie Chiu-wing Yeung, David So, Suzanne Ho-wai Ma, Suk Ling Lam, Linda Chiu Wah Leung, Chi Ming Lee, Sing Sci Rep Article It is unknown if young medication-naïve bipolar II (BPII) depressed patients have increased white matter (WM) disruptions. 27 each of young (average 23 years) and treatment-naïve BPII depressed, unipolar depressed (UD) patients and age–sex–education matched healthy controls (HC) underwent 3 T MRIs with diffusion tensor imaging. Diagnostic ratings included Structured Clinical Interview for DSM Disorders (SCID), Montgomery-Åsberg Depression Rating Scale (MADRS), Young Mania Rating Scale (YMRS) and Hamilton Anxiety Rating Scale (HAM-A). Patients were clinically depressed (MADRS-BPII: 26.15 [SD9.25], UD: 25.56 [5.24], p = 0.86). Compared to UD, BPII had increased family bipolarity (BPII 13.6% vs UD 2.5%, p = 0.01, φc = 0.28), hypomanic symptoms (YMRS-BPII: 4.22 [4.24], UD: 1.33 [2], p = 0.02, d = 0.87), lifetime number of depressive episodes (BPII: 2.37 [1.23], UD: 1.44 [0.75], p = 0.02, d = 0.91), lifetime and current-year number of episodes (lifetime BPII: 50.85 [95.47], UD: 1.7 [1.03]; current-year BPII: 9.93 [16.29], UD: 1.11 [0.32], ps = 0.04, ds = 0.73–0.77) and longer illness duration (BPII: 4.96 years [3.96], UD: 2.99 [3.33], p = 0.15, d = 0.54). BPII showed no increased WM disruptions vs UD or HC in any of the 15 a priori WM tracts. UD had lower right superior longitudinal fasciculus (SLF) (temporal) axial diffusivity (AD) (1.14 vs 1.17 (BPII), 1.16 (HC); F = 6.93, 95% CI of [Formula: see text] : 0.00073, 5.22, ηp(2) = 0.15). Principal component analysis followed by exploratory linear discriminant analysis showed that increased R-SLF (temporal) AD, YMRS and family bipolarity distinguished BPII from UD (81.5% sensitivity, 85.2% specificity) independent of episode number and frequency. Young, medication-naïve adults with BPII depression did not show the WM disruptions distinguishing more chronically ill BP patients from UD. These WM disruptions may therefore be partly attributable to illness chronicity. Longitudinal studies should examine the trajectory of WM changes in BPII and UD and predictive validity of these baseline clinical and imaging parameters. Nature Publishing Group UK 2021-01-19 /pmc/articles/PMC7815920/ /pubmed/33469064 http://dx.doi.org/10.1038/s41598-021-81355-9 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Mak, Arthur Dun Ping
Leung, Owen Ngo Wang
Chou, Idy Wing Yi
Wong, Sheila Lok Yiu
Chu, Winnie Chiu-wing
Yeung, David
So, Suzanne Ho-wai
Ma, Suk Ling
Lam, Linda Chiu Wah
Leung, Chi Ming
Lee, Sing
White matter integrity in young medication-naïve bipolar II depressed adults
title White matter integrity in young medication-naïve bipolar II depressed adults
title_full White matter integrity in young medication-naïve bipolar II depressed adults
title_fullStr White matter integrity in young medication-naïve bipolar II depressed adults
title_full_unstemmed White matter integrity in young medication-naïve bipolar II depressed adults
title_short White matter integrity in young medication-naïve bipolar II depressed adults
title_sort white matter integrity in young medication-naïve bipolar ii depressed adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815920/
https://www.ncbi.nlm.nih.gov/pubmed/33469064
http://dx.doi.org/10.1038/s41598-021-81355-9
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