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Insights into the Structure-Activity Relationship of Glycosides as Positive Allosteric Modulators Acting on P2X7 Receptors

P2X7 is an important ligand-gated ion channel expressed in multiple immune cell populations. This study aimed to investigate the chemical requirements of triterpenoid glycosides within a new binding pocket to characterize the structure-activity relationship. A set of glycosides were screened for pos...

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Detalles Bibliográficos
Autores principales:	Piyasirananda, Waraporn, Beekman, Andrew, Ganesan, A., Bidula, Stefan, Stokes, Leanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816042/ https://www.ncbi.nlm.nih.gov/pubmed/33334897 http://dx.doi.org/10.1124/molpharm.120.000129

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