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Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients

BACKGROUND: There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbiditie...

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Autores principales: Tchana-Sato, Vincent, Ancion, Arnaud, Tridetti, Julien, Sakalihasan, Natzi, Hayette, Marie Pierre, Detry, Olivier, Delvenne, Philippe, Amabili, Philippe, Senard, Marc, Hougrand, Olivier, Szecel, Delphine, Lavigne, Jean-Paul, Minga Lowampa, Elie, Ponte, Charlotte, Maquoi, Isabelle, Morimont, Philippe, Van Den Bulck, Melissa, Delbouille, Marie Helene, Defraigne, Jean Olivier, Lancellotti, Patrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816134/
https://www.ncbi.nlm.nih.gov/pubmed/33472599
http://dx.doi.org/10.1186/s12879-021-05793-6
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author Tchana-Sato, Vincent
Ancion, Arnaud
Tridetti, Julien
Sakalihasan, Natzi
Hayette, Marie Pierre
Detry, Olivier
Delvenne, Philippe
Amabili, Philippe
Senard, Marc
Hougrand, Olivier
Szecel, Delphine
Lavigne, Jean-Paul
Minga Lowampa, Elie
Ponte, Charlotte
Maquoi, Isabelle
Morimont, Philippe
Van Den Bulck, Melissa
Delbouille, Marie Helene
Defraigne, Jean Olivier
Lancellotti, Patrizio
author_facet Tchana-Sato, Vincent
Ancion, Arnaud
Tridetti, Julien
Sakalihasan, Natzi
Hayette, Marie Pierre
Detry, Olivier
Delvenne, Philippe
Amabili, Philippe
Senard, Marc
Hougrand, Olivier
Szecel, Delphine
Lavigne, Jean-Paul
Minga Lowampa, Elie
Ponte, Charlotte
Maquoi, Isabelle
Morimont, Philippe
Van Den Bulck, Melissa
Delbouille, Marie Helene
Defraigne, Jean Olivier
Lancellotti, Patrizio
author_sort Tchana-Sato, Vincent
collection PubMed
description BACKGROUND: There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. CASE PRESENTATION: This report describes the clinical course and the challenging management of early COVID-19 infection in two heart transplant recipients who tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. CONCLUSIONS: These two cases illustrate the severity and poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory, and the issue of asymptomatic carriers needs to be addressed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-05793-6.
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spelling pubmed-78161342021-01-21 Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients Tchana-Sato, Vincent Ancion, Arnaud Tridetti, Julien Sakalihasan, Natzi Hayette, Marie Pierre Detry, Olivier Delvenne, Philippe Amabili, Philippe Senard, Marc Hougrand, Olivier Szecel, Delphine Lavigne, Jean-Paul Minga Lowampa, Elie Ponte, Charlotte Maquoi, Isabelle Morimont, Philippe Van Den Bulck, Melissa Delbouille, Marie Helene Defraigne, Jean Olivier Lancellotti, Patrizio BMC Infect Dis Case Report BACKGROUND: There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially in heart transplant recipients, with only a few case reports and case series described so far. Heart transplant recipients may be at particular high risk due to their comorbidities and immunosuppressed state. CASE PRESENTATION: This report describes the clinical course and the challenging management of early COVID-19 infection in two heart transplant recipients who tested positive for the SARS-CoV-2 virus in the perioperative period of the transplant procedure. The two patients developed a severe form of the disease and ultimately died despite the initiation of an antiviral monotherapy with hydroxychloroquine coupled with the interruption of mycophenolate mofetil. CONCLUSIONS: These two cases illustrate the severity and poor prognosis of COVID-19 in the perioperative period of a heart transplant. Thorough screening of donors and recipients is mandatory, and the issue of asymptomatic carriers needs to be addressed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-05793-6. BioMed Central 2021-01-20 /pmc/articles/PMC7816134/ /pubmed/33472599 http://dx.doi.org/10.1186/s12879-021-05793-6 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Tchana-Sato, Vincent
Ancion, Arnaud
Tridetti, Julien
Sakalihasan, Natzi
Hayette, Marie Pierre
Detry, Olivier
Delvenne, Philippe
Amabili, Philippe
Senard, Marc
Hougrand, Olivier
Szecel, Delphine
Lavigne, Jean-Paul
Minga Lowampa, Elie
Ponte, Charlotte
Maquoi, Isabelle
Morimont, Philippe
Van Den Bulck, Melissa
Delbouille, Marie Helene
Defraigne, Jean Olivier
Lancellotti, Patrizio
Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients
title Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients
title_full Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients
title_fullStr Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients
title_full_unstemmed Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients
title_short Clinical course and challenging management of early COVID-19 infection after heart transplantation: case report of two patients
title_sort clinical course and challenging management of early covid-19 infection after heart transplantation: case report of two patients
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816134/
https://www.ncbi.nlm.nih.gov/pubmed/33472599
http://dx.doi.org/10.1186/s12879-021-05793-6
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