Structure–Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D

[Image: see text] N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is regarded as the main enzyme responsible for the biosynthesis of N-acylethanolamines (NAEs), a family of bioactive lipid mediators. Previously, we reported N-(cyclopropylmethyl)-6-((S)-3-hydroxypyrrolidin-1-yl)-2-((S)-3-ph...

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Detalles Bibliográficos
Autores principales: Mock, Elliot D., Kotsogianni, Ioli, Driever, Wouter P. F., Fonseca, Carmen S., Vooijs, Jelle M., den Dulk, Hans, van Boeckel, Constant A. A., van der Stelt, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816197/
https://www.ncbi.nlm.nih.gov/pubmed/33382264
http://dx.doi.org/10.1021/acs.jmedchem.0c01441

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