Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease

The familial form of Parkinson’s disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, because mitochondria are highly...

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Autores principales: Kamienieva, Iryna, Duszyński, Jerzy, Szczepanowska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816312/
https://www.ncbi.nlm.nih.gov/pubmed/33468256
http://dx.doi.org/10.1186/s40035-020-00229-8
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author Kamienieva, Iryna
Duszyński, Jerzy
Szczepanowska, Joanna
author_facet Kamienieva, Iryna
Duszyński, Jerzy
Szczepanowska, Joanna
author_sort Kamienieva, Iryna
collection PubMed
description The familial form of Parkinson’s disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, because mitochondria are highly dynamic structures integrated with many cellular functions. Herein, we overview and discuss the role of the parkin protein product, Parkin E3 ubiquitin ligase, in the cellular processes related to mitochondrial function, and how parkin mutations can result in pathology in vitro and in vivo.
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spelling pubmed-78163122021-01-21 Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease Kamienieva, Iryna Duszyński, Jerzy Szczepanowska, Joanna Transl Neurodegener Review The familial form of Parkinson’s disease (PD) is linked to mutations in specific genes. The mutations in parkin are one of the most common causes of early-onset PD. Mitochondrial dysfunction is an emerging active player in the pathology of neurodegenerative diseases, because mitochondria are highly dynamic structures integrated with many cellular functions. Herein, we overview and discuss the role of the parkin protein product, Parkin E3 ubiquitin ligase, in the cellular processes related to mitochondrial function, and how parkin mutations can result in pathology in vitro and in vivo. BioMed Central 2021-01-20 /pmc/articles/PMC7816312/ /pubmed/33468256 http://dx.doi.org/10.1186/s40035-020-00229-8 Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Kamienieva, Iryna
Duszyński, Jerzy
Szczepanowska, Joanna
Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title_full Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title_fullStr Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title_full_unstemmed Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title_short Multitasking guardian of mitochondrial quality: Parkin function and Parkinson’s disease
title_sort multitasking guardian of mitochondrial quality: parkin function and parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816312/
https://www.ncbi.nlm.nih.gov/pubmed/33468256
http://dx.doi.org/10.1186/s40035-020-00229-8
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