Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

BACKGROUND: TNBC is the most aggressive breast cancer with higher recurrence and mortality rate than other types of breast cancer. There is an urgent need for identification of therapeutic agents with unique mode of action for overcoming current challenges in TNBC treatment. METHODS: Different inhib...

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Detalles Bibliográficos
Autores principales: Ding, Yahui, Chen, Xiaoping, Liu, Can, Ge, Weizhi, Wang, Qin, Hao, Xin, Wang, Mengmeng, Chen, Yue, Zhang, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816340/
https://www.ncbi.nlm.nih.gov/pubmed/33472669
http://dx.doi.org/10.1186/s13045-020-01016-8

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