Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes

Genome-wide CRISPR screens have transformed our ability to systematically interrogate human gene function, but are currently limited to a subset of cellular phenotypes. We report a novel pooled screening approach for a wider range of cellular and subtle subcellular phenotypes. Machine learning and c...

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Detalles Bibliográficos
Autores principales: Kanfer, Gil, Sarraf, Shireen A., Maman, Yaakov, Baldwin, Heather, Dominguez-Martin, Eunice, Johnson, Kory R., Ward, Michael E., Kampmann, Martin, Lippincott-Schwartz, Jennifer, Youle, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Tools
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816647/
https://www.ncbi.nlm.nih.gov/pubmed/33464298
http://dx.doi.org/10.1083/jcb.202006180

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