The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates

α-Synuclein amyloid self-assembly is the hallmark of a number of neurodegenerative disorders, including Parkinson's disease, although there is still very limited understanding about the factors and mechanisms that trigger this process. Primary nucleation has been observed to be initiated in vit...

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Detalles Bibliográficos
Autores principales: Camino, José D., Gracia, Pablo, Chen, Serene W., Sot, Jesús, de la Arada, Igor, Sebastián, Víctor, Arrondo, José L. R., Goñi, Félix M., Dobson, Christopher M., Cremades, Nunilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816767/
https://www.ncbi.nlm.nih.gov/pubmed/33520152
http://dx.doi.org/10.1039/d0sc05297c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816767/
https://www.ncbi.nlm.nih.gov/pubmed/33520152
http://dx.doi.org/10.1039/d0sc05297c

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