Blood omega-3 fatty acids and death from COVID-19: A pilot study

Very-long chain omega-3 fatty acids (EPA and DHA) have anti-inflammatory properties that may help reduce morbidity and mortality from COVID-19 infection. We conducted a pilot study in 100 patients to test the hypothesis that RBC EPA+DHA levels (the Omega-3 Index, O3I) would be inversely associated w...

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Autores principales: Asher, Arash, Tintle, Nathan L., Myers, Michael, Lockshon, Laura, Bacareza, Heribert, Harris, William S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816864/
https://www.ncbi.nlm.nih.gov/pubmed/33516093
http://dx.doi.org/10.1016/j.plefa.2021.102250
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author Asher, Arash
Tintle, Nathan L.
Myers, Michael
Lockshon, Laura
Bacareza, Heribert
Harris, William S.
author_facet Asher, Arash
Tintle, Nathan L.
Myers, Michael
Lockshon, Laura
Bacareza, Heribert
Harris, William S.
author_sort Asher, Arash
collection PubMed
description Very-long chain omega-3 fatty acids (EPA and DHA) have anti-inflammatory properties that may help reduce morbidity and mortality from COVID-19 infection. We conducted a pilot study in 100 patients to test the hypothesis that RBC EPA+DHA levels (the Omega-3 Index, O3I) would be inversely associated with risk for death by analyzing the O3I in banked blood samples drawn at hospital admission. Fourteen patients died, one of 25 in quartile 4 (Q4) (O3I ≥5.7%) and 13 of 75 in Q1–3. After adjusting for age and sex, the odds ratio for death in patients with an O3I in Q4 vs Q1–3 was 0.25, p = 0.07. Although not meeting the classical criteria for statistical significance, this strong trend suggests that a relationship may indeed exist, but more well-powered studies are clearly needed.
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spelling pubmed-78168642021-01-21 Blood omega-3 fatty acids and death from COVID-19: A pilot study Asher, Arash Tintle, Nathan L. Myers, Michael Lockshon, Laura Bacareza, Heribert Harris, William S. Prostaglandins Leukot Essent Fatty Acids Short Communication Very-long chain omega-3 fatty acids (EPA and DHA) have anti-inflammatory properties that may help reduce morbidity and mortality from COVID-19 infection. We conducted a pilot study in 100 patients to test the hypothesis that RBC EPA+DHA levels (the Omega-3 Index, O3I) would be inversely associated with risk for death by analyzing the O3I in banked blood samples drawn at hospital admission. Fourteen patients died, one of 25 in quartile 4 (Q4) (O3I ≥5.7%) and 13 of 75 in Q1–3. After adjusting for age and sex, the odds ratio for death in patients with an O3I in Q4 vs Q1–3 was 0.25, p = 0.07. Although not meeting the classical criteria for statistical significance, this strong trend suggests that a relationship may indeed exist, but more well-powered studies are clearly needed. Elsevier Ltd. 2021-03 2021-01-20 /pmc/articles/PMC7816864/ /pubmed/33516093 http://dx.doi.org/10.1016/j.plefa.2021.102250 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Asher, Arash
Tintle, Nathan L.
Myers, Michael
Lockshon, Laura
Bacareza, Heribert
Harris, William S.
Blood omega-3 fatty acids and death from COVID-19: A pilot study
title Blood omega-3 fatty acids and death from COVID-19: A pilot study
title_full Blood omega-3 fatty acids and death from COVID-19: A pilot study
title_fullStr Blood omega-3 fatty acids and death from COVID-19: A pilot study
title_full_unstemmed Blood omega-3 fatty acids and death from COVID-19: A pilot study
title_short Blood omega-3 fatty acids and death from COVID-19: A pilot study
title_sort blood omega-3 fatty acids and death from covid-19: a pilot study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816864/
https://www.ncbi.nlm.nih.gov/pubmed/33516093
http://dx.doi.org/10.1016/j.plefa.2021.102250
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