IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages

INTRODUCTION: Anti-inflammatory cytokine IL-10 suppresses pro-inflammatory IL-12b expression after Lipopolysaccharide (LPS) stimulation in colonic macrophages, as part of the innate immunity Toll-Like Receptor (TLR)-NF-κB activation system. This homeostatic mechanism limits excess inflammation in th...

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Detalles Bibliográficos
Autores principales: Stanfield, Brent A., Purves, Todd, Palmer, Scott, Sullenger, Bruce, Welty-Wolf, Karen, Haines, Krista, Agarwal, Suresh, Kasotakis, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7816993/
https://www.ncbi.nlm.nih.gov/pubmed/33471802
http://dx.doi.org/10.1371/journal.pone.0245169

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