Network propagation of rare variants in Alzheimer’s disease reveals tissue-specific hub genes and communities

State-of-the-art rare variant association testing methods aggregate the contribution of rare variants in biologically relevant genomic regions to boost statistical power. However, testing single genes separately does not consider the complex interaction landscape of genes, nor the downstream effects...

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Detalles Bibliográficos
Autores principales: Scelsi, Marzia Antonella, Napolioni, Valerio, Greicius, Michael D., Altmann, Andre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817020/
https://www.ncbi.nlm.nih.gov/pubmed/33411734
http://dx.doi.org/10.1371/journal.pcbi.1008517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817020/
https://www.ncbi.nlm.nih.gov/pubmed/33411734
http://dx.doi.org/10.1371/journal.pcbi.1008517

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