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Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions
Bistability is a common mechanism to ensure robust and irreversible cell cycle transitions. Whenever biological parameters or external conditions change such that a threshold is crossed, the system abruptly switches between different cell cycle states. Experimental studies have uncovered mechanisms...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817062/ https://www.ncbi.nlm.nih.gov/pubmed/33411761 http://dx.doi.org/10.1371/journal.pcbi.1008231 |
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author | Rombouts, Jan Gelens, Lendert |
author_facet | Rombouts, Jan Gelens, Lendert |
author_sort | Rombouts, Jan |
collection | PubMed |
description | Bistability is a common mechanism to ensure robust and irreversible cell cycle transitions. Whenever biological parameters or external conditions change such that a threshold is crossed, the system abruptly switches between different cell cycle states. Experimental studies have uncovered mechanisms that can make the shape of the bistable response curve change dynamically in time. Here, we show how such a dynamically changing bistable switch can provide a cell with better control over the timing of cell cycle transitions. Moreover, cell cycle oscillations built on bistable switches are more robust when the bistability is modulated in time. Our results are not specific to cell cycle models and may apply to other bistable systems in which the bistable response curve is time-dependent. |
format | Online Article Text |
id | pubmed-7817062 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-78170622021-01-28 Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions Rombouts, Jan Gelens, Lendert PLoS Comput Biol Research Article Bistability is a common mechanism to ensure robust and irreversible cell cycle transitions. Whenever biological parameters or external conditions change such that a threshold is crossed, the system abruptly switches between different cell cycle states. Experimental studies have uncovered mechanisms that can make the shape of the bistable response curve change dynamically in time. Here, we show how such a dynamically changing bistable switch can provide a cell with better control over the timing of cell cycle transitions. Moreover, cell cycle oscillations built on bistable switches are more robust when the bistability is modulated in time. Our results are not specific to cell cycle models and may apply to other bistable systems in which the bistable response curve is time-dependent. Public Library of Science 2021-01-07 /pmc/articles/PMC7817062/ /pubmed/33411761 http://dx.doi.org/10.1371/journal.pcbi.1008231 Text en © 2021 Rombouts, Gelens http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Rombouts, Jan Gelens, Lendert Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions |
title | Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions |
title_full | Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions |
title_fullStr | Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions |
title_full_unstemmed | Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions |
title_short | Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions |
title_sort | dynamic bistable switches enhance robustness and accuracy of cell cycle transitions |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817062/ https://www.ncbi.nlm.nih.gov/pubmed/33411761 http://dx.doi.org/10.1371/journal.pcbi.1008231 |
work_keys_str_mv | AT romboutsjan dynamicbistableswitchesenhancerobustnessandaccuracyofcellcycletransitions AT gelenslendert dynamicbistableswitchesenhancerobustnessandaccuracyofcellcycletransitions |