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Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions

Bistability is a common mechanism to ensure robust and irreversible cell cycle transitions. Whenever biological parameters or external conditions change such that a threshold is crossed, the system abruptly switches between different cell cycle states. Experimental studies have uncovered mechanisms...

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Detalles Bibliográficos
Autores principales: Rombouts, Jan, Gelens, Lendert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817062/
https://www.ncbi.nlm.nih.gov/pubmed/33411761
http://dx.doi.org/10.1371/journal.pcbi.1008231
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author Rombouts, Jan
Gelens, Lendert
author_facet Rombouts, Jan
Gelens, Lendert
author_sort Rombouts, Jan
collection PubMed
description Bistability is a common mechanism to ensure robust and irreversible cell cycle transitions. Whenever biological parameters or external conditions change such that a threshold is crossed, the system abruptly switches between different cell cycle states. Experimental studies have uncovered mechanisms that can make the shape of the bistable response curve change dynamically in time. Here, we show how such a dynamically changing bistable switch can provide a cell with better control over the timing of cell cycle transitions. Moreover, cell cycle oscillations built on bistable switches are more robust when the bistability is modulated in time. Our results are not specific to cell cycle models and may apply to other bistable systems in which the bistable response curve is time-dependent.
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spelling pubmed-78170622021-01-28 Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions Rombouts, Jan Gelens, Lendert PLoS Comput Biol Research Article Bistability is a common mechanism to ensure robust and irreversible cell cycle transitions. Whenever biological parameters or external conditions change such that a threshold is crossed, the system abruptly switches between different cell cycle states. Experimental studies have uncovered mechanisms that can make the shape of the bistable response curve change dynamically in time. Here, we show how such a dynamically changing bistable switch can provide a cell with better control over the timing of cell cycle transitions. Moreover, cell cycle oscillations built on bistable switches are more robust when the bistability is modulated in time. Our results are not specific to cell cycle models and may apply to other bistable systems in which the bistable response curve is time-dependent. Public Library of Science 2021-01-07 /pmc/articles/PMC7817062/ /pubmed/33411761 http://dx.doi.org/10.1371/journal.pcbi.1008231 Text en © 2021 Rombouts, Gelens http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Rombouts, Jan
Gelens, Lendert
Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions
title Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions
title_full Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions
title_fullStr Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions
title_full_unstemmed Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions
title_short Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions
title_sort dynamic bistable switches enhance robustness and accuracy of cell cycle transitions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817062/
https://www.ncbi.nlm.nih.gov/pubmed/33411761
http://dx.doi.org/10.1371/journal.pcbi.1008231
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