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Enhancement strategies for transdermal drug delivery systems: current trends and applications
Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parent...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817074/ https://www.ncbi.nlm.nih.gov/pubmed/33474709 http://dx.doi.org/10.1007/s13346-021-00909-6 |
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author | Ramadon, Delly McCrudden, Maeliosa T. C. Courtenay, Aaron J. Donnelly, Ryan F. |
author_facet | Ramadon, Delly McCrudden, Maeliosa T. C. Courtenay, Aaron J. Donnelly, Ryan F. |
author_sort | Ramadon, Delly |
collection | PubMed |
description | Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-7817074 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-78170742021-01-21 Enhancement strategies for transdermal drug delivery systems: current trends and applications Ramadon, Delly McCrudden, Maeliosa T. C. Courtenay, Aaron J. Donnelly, Ryan F. Drug Deliv Transl Res Original Article Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2021-01-20 2022 /pmc/articles/PMC7817074/ /pubmed/33474709 http://dx.doi.org/10.1007/s13346-021-00909-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Ramadon, Delly McCrudden, Maeliosa T. C. Courtenay, Aaron J. Donnelly, Ryan F. Enhancement strategies for transdermal drug delivery systems: current trends and applications |
title | Enhancement strategies for transdermal drug delivery systems: current trends and applications |
title_full | Enhancement strategies for transdermal drug delivery systems: current trends and applications |
title_fullStr | Enhancement strategies for transdermal drug delivery systems: current trends and applications |
title_full_unstemmed | Enhancement strategies for transdermal drug delivery systems: current trends and applications |
title_short | Enhancement strategies for transdermal drug delivery systems: current trends and applications |
title_sort | enhancement strategies for transdermal drug delivery systems: current trends and applications |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817074/ https://www.ncbi.nlm.nih.gov/pubmed/33474709 http://dx.doi.org/10.1007/s13346-021-00909-6 |
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