Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement

We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring...

Descripción completa

Detalles Bibliográficos
Autores principales: Narayanasamy, Shanti, Nation, Roger L, Mahony, Andrew A, Grayson, M Lindsay, Kwong, Jason C, Sherry, Norelle L, Khumra, Sharmila, Ellis, Andrew G, Frauman, Albert G, Holmes, Natasha E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Novel ID Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817083/
https://www.ncbi.nlm.nih.gov/pubmed/33511225
http://dx.doi.org/10.1093/ofid/ofaa572
_version_ 1783638572340871168
author Narayanasamy, Shanti
Nation, Roger L
Mahony, Andrew A
Grayson, M Lindsay
Kwong, Jason C
Sherry, Norelle L
Khumra, Sharmila
Ellis, Andrew G
Frauman, Albert G
Holmes, Natasha E
author_facet Narayanasamy, Shanti
Nation, Roger L
Mahony, Andrew A
Grayson, M Lindsay
Kwong, Jason C
Sherry, Norelle L
Khumra, Sharmila
Ellis, Andrew G
Frauman, Albert G
Holmes, Natasha E
author_sort Narayanasamy, Shanti
collection PubMed
description We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.
format Online
Article
Text
id pubmed-7817083
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-78170832021-01-27 Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement Narayanasamy, Shanti Nation, Roger L Mahony, Andrew A Grayson, M Lindsay Kwong, Jason C Sherry, Norelle L Khumra, Sharmila Ellis, Andrew G Frauman, Albert G Holmes, Natasha E Open Forum Infect Dis Novel ID Cases We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity. Oxford University Press 2020-11-26 /pmc/articles/PMC7817083/ /pubmed/33511225 http://dx.doi.org/10.1093/ofid/ofaa572 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Novel ID Cases
Narayanasamy, Shanti
Nation, Roger L
Mahony, Andrew A
Grayson, M Lindsay
Kwong, Jason C
Sherry, Norelle L
Khumra, Sharmila
Ellis, Andrew G
Frauman, Albert G
Holmes, Natasha E
Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement
title Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement
title_full Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement
title_fullStr Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement
title_full_unstemmed Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement
title_short Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement
title_sort cure of limb-threatening xdr pseudomonas aeruginosa infection: combining genome sequencing, therapeutic drug level monitoring, and surgical debridement
topic Novel ID Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817083/
https://www.ncbi.nlm.nih.gov/pubmed/33511225
http://dx.doi.org/10.1093/ofid/ofaa572
work_keys_str_mv AT narayanasamyshanti cureoflimbthreateningxdrpseudomonasaeruginosainfectioncombininggenomesequencingtherapeuticdruglevelmonitoringandsurgicaldebridement
AT nationrogerl cureoflimbthreateningxdrpseudomonasaeruginosainfectioncombininggenomesequencingtherapeuticdruglevelmonitoringandsurgicaldebridement
AT mahonyandrewa cureoflimbthreateningxdrpseudomonasaeruginosainfectioncombininggenomesequencingtherapeuticdruglevelmonitoringandsurgicaldebridement
AT graysonmlindsay cureoflimbthreateningxdrpseudomonasaeruginosainfectioncombininggenomesequencingtherapeuticdruglevelmonitoringandsurgicaldebridement
AT kwongjasonc cureoflimbthreateningxdrpseudomonasaeruginosainfectioncombininggenomesequencingtherapeuticdruglevelmonitoringandsurgicaldebridement
AT sherrynorellel cureoflimbthreateningxdrpseudomonasaeruginosainfectioncombininggenomesequencingtherapeuticdruglevelmonitoringandsurgicaldebridement
AT khumrasharmila cureoflimbthreateningxdrpseudomonasaeruginosainfectioncombininggenomesequencingtherapeuticdruglevelmonitoringandsurgicaldebridement
AT ellisandrewg cureoflimbthreateningxdrpseudomonasaeruginosainfectioncombininggenomesequencingtherapeuticdruglevelmonitoringandsurgicaldebridement
AT fraumanalbertg cureoflimbthreateningxdrpseudomonasaeruginosainfectioncombininggenomesequencingtherapeuticdruglevelmonitoringandsurgicaldebridement
AT holmesnatashae cureoflimbthreateningxdrpseudomonasaeruginosainfectioncombininggenomesequencingtherapeuticdruglevelmonitoringandsurgicaldebridement

Ejemplares similares