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The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins

5-Methylcytosine (5mC) oxidases, the ten-eleven translocation (TET) proteins, initiate DNA demethylation, but it is unclear how 5mC oxidation is regulated. We show that the protein SMCHD1 (structural maintenance of chromosomes flexible hinge domain containing 1) is found in complexes with TET protei...

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Detalles Bibliográficos
Autores principales:	Huang, Zhijun, Yu, Jiyoung, Cui, Wei, Johnson, Benjamin K., Kim, Kyunggon, Pfeifer, Gerd P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817097/ https://www.ncbi.nlm.nih.gov/pubmed/33523915 http://dx.doi.org/10.1126/sciadv.abb9149

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