Safe harbor-targeted CRISPR-Cas9 homology-independent targeted integration for multimodality reporter gene-based cell tracking

Imaging reporter genes provides longitudinal information on the biodistribution, growth, and survival of engineered cells in vivo. A translational bottleneck to using reporter genes is the necessity to engineer cells with randomly integrating vectors. Here, we built homology-independent targeted int...

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Detalles Bibliográficos
Autores principales: Kelly, John J., Saee-Marand, Moe, Nyström, Nivin N., Evans, Melissa M., Chen, Yuanxin, Martinez, Francisco M., Hamilton, Amanda M., Ronald, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817109/
https://www.ncbi.nlm.nih.gov/pubmed/33523917
http://dx.doi.org/10.1126/sciadv.abc3791

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