Cargando…

Mechanistic insights into the synergistic activation of the RXR–PXR heterodimer by endocrine disruptor mixtures

Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-disrupting chemicals (EDCs). A vast body of literature links exposure to these chemicals with increased incidences of reproductive, metabolic, or neurological disorders. Moreover, recent data demonstrate that, when us...

Descripción completa

Detalles Bibliográficos
Autores principales:	Delfosse, Vanessa, Huet, Tiphaine, Harrus, Deborah, Granell, Meritxell, Bourguet, Maxime, Gardia-Parège, Caroline, Chiavarina, Barbara, Grimaldi, Marina, Le Mével, Sébastien, Blanc, Pauline, Huang, David, Gruszczyk, Jakub, Demeneix, Barbara, Cianférani, Sarah, Fini, Jean-Baptiste, Balaguer, Patrick, Bourguet, William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817120/ https://www.ncbi.nlm.nih.gov/pubmed/33361153 http://dx.doi.org/10.1073/pnas.2020551118

Ejemplares similares

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations
por: le Maire, Albane, et al.
Publicado: (2019)

Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer
por: Belorusova, Anna Y, et al.
Publicado: (2020)

Reporter Cell Lines for the Characterization of the Interactions between Human Nuclear Receptors and Endocrine Disruptors
por: Grimaldi, Marina, et al.
Publicado: (2015)

Human pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alpha
por: Conde, Isabel, et al.
Publicado: (2008)

A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays
por: Creusot, Nicolas, et al.
Publicado: (2021)

Steatosis and Metabolic Disorders Associated with Synergistic Activation of the CAR/RXR Heterodimer by Pesticides
por: Dauwe, Yannick, et al.
Publicado: (2023)

In Silico Predictions of Endocrine Disruptors Properties
por: Schneider, Melanie, et al.
Publicado: (2019)

Structural basis for DNA recognition and allosteric control of the retinoic acid receptors RAR–RXR
por: Osz, Judit, et al.
Publicado: (2020)

Structural and Functional Profiling of Environmental Ligands for Estrogen Receptors
por: Delfosse, Vanessa, et al.
Publicado: (2014)

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers
por: Kojetin, Douglas J., et al.
Publicado: (2015)

Reporter cell lines to evaluate the selectivity of chemicals for human and zebrafish estrogen and peroxysome proliferator activated γ receptors
por: Grimaldi, Marina, et al.
Publicado: (2015)

SAT006 Activation Of The CAR/RXR Heterodimer By Pesticides And Induced Metabolic Effects
por: Dauwe, Yannick, et al.
Publicado: (2023)

Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective
por: Demeneix, Barbara, et al.
Publicado: (2020)

The quaternary architecture of RARβ–RXRα heterodimer facilitates domain–domain signal transmission
por: Chandra, Vikas, et al.
Publicado: (2017)

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds
por: Delfosse, Vanessa, et al.
Publicado: (2015)

Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer
por: Zhao, Mohan, et al.
Publicado: (2022)

An integrated structure- and system-based framework to identify new targets of metabolites and known drugs
por: Naveed, Hammad, et al.
Publicado: (2015)

Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes
por: Ning, Rui, et al.
Publicado: (2017)

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project
por: Braeuning, Albert, et al.
Publicado: (2023)

Heterodimer formation with retinoic acid receptor RXRα modulates coactivator recruitment by peroxisome proliferator-activated receptor PPARγ
por: Kilu, Whitney, et al.
Publicado: (2021)

Observations on a Case of Paralysis of the Extensor Muscles of the Hand and Fingers, Accompanied with a Separation of the Bones of the Metacarpus
por: Bourguet,
Publicado: (1800)

Functional analyses of phosphatidylserine/PI(4)P exchangers with diverse lipid species and membrane contexts reveal unanticipated rules on lipid transfer
por: Ikhlef, Souade, et al.
Publicado: (2021)

RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury
por: van Neerven, Sabien, et al.
Publicado: (2007)

A Mixture of Chemicals Found in Human Amniotic Fluid Disrupts Brain Gene Expression and Behavior in Xenopus laevis
por: Leemans, Michelle, et al.
Publicado: (2023)

The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages
por: Daniel, Bence, et al.
Publicado: (2018)

Correction for Zhao et al., Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXRα heterodimer
Publicado: (2023)

An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist
por: Nadendla, Eswarkumar, et al.
Publicado: (2015)

T-Cell Death-Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis
por: Kim, Sumi, et al.
Publicado: (2021)

A Rapid, Physiologic Protocol for Testing Transcriptional Effects of Thyroid-Disrupting Agents in Premetamorphic Xenopus Tadpoles
por: Turque, Nathalie, et al.
Publicado: (2005)

La pintura paleocristiana
por: Bourguet, Pierre du
Publicado: (1967)

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization
por: Scheepstra, Marcel, et al.
Publicado: (2017)

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers
por: de Saint-Jean, Maud, et al.
Publicado: (2011)

Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos
por: Fini, Jean-Baptiste, et al.
Publicado: (2017)

Analysis of RXR/THR and RXR/PPARG2 Heterodimerization by Bioluminescence Resonance Energy Transfer (BRET)
por: Mulero, Miquel, et al.
Publicado: (2013)

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex
por: Gruszczyk, Jakub, et al.
Publicado: (2022)

Attenuation of Colon Inflammation through Activators of the Retinoid X Receptor (Rxr)/Peroxisome Proliferator–Activated Receptor γ (Pparγ) Heterodimer: A Basis for New Therapeutic Strategies
por: Desreumaux, Pierre, et al.
Publicado: (2001)

A Semi-throughput Procedure for Assaying Plant NADP-malate Dehydrogenase Activity Using a Plate Reader
por: Baudry, Kevin, et al.
Publicado: (2023)

The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
por: Lupu, Diana, et al.
Publicado: (2020)

Thyroid-disrupting chemicals and brain development: an update
por: Mughal, Bilal B, et al.
Publicado: (2018)

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data
por: Leemans, Michelle, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hhhc6mkugsvojrc3utnoqrbkma