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The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release

Inositol-1,4,5-triphosphate (IP(3)) kinase B (ITPKB) is a ubiquitously expressed lipid kinase that inactivates IP(3), a secondary messenger that stimulates calcium release from the endoplasmic reticulum (ER). Genome-wide association studies have identified common variants in the ITPKB gene locus ass...

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Detalles Bibliográficos
Autores principales:	Apicco, Daniel J., Shlevkov, Evgeny, Nezich, Catherine L., Tran, David T., Guilmette, Edward, Nicholatos, Justin W., Bantle, Collin M., Chen, Yi, Glajch, Kelly E., Abraham, Neeta A., Dang, Lan T., Kaynor, G. Campbell, Tsai, Ellen A., Nguyen, Khanh-Dung H., Groot, Joost, Liu, YuTing, Weihofen, Andreas, Hurt, Jessica A., Runz, Heiko, Hirst, Warren D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2021
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817155/ https://www.ncbi.nlm.nih.gov/pubmed/33443159 http://dx.doi.org/10.1073/pnas.2006476118

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