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Improving preclinical studies through replications

The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans. However, a substantial number of clinical trials fail, even when preclinical studi...

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Autores principales: Drude, Natascha Ingrid, Martinez Gamboa, Lorena, Danziger, Meggie, Dirnagl, Ulrich, Toelch, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817176/
https://www.ncbi.nlm.nih.gov/pubmed/33432925
http://dx.doi.org/10.7554/eLife.62101
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author Drude, Natascha Ingrid
Martinez Gamboa, Lorena
Danziger, Meggie
Dirnagl, Ulrich
Toelch, Ulf
author_facet Drude, Natascha Ingrid
Martinez Gamboa, Lorena
Danziger, Meggie
Dirnagl, Ulrich
Toelch, Ulf
author_sort Drude, Natascha Ingrid
collection PubMed
description The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans. However, a substantial number of clinical trials fail, even when preclinical studies have apparently demonstrated the efficacy of a given intervention. A number of large-scale replication studies are currently trying to identify the factors that influence the robustness of preclinical research. Here, we discuss replications in the context of preclinical research trajectories, and argue that increasing validity should be a priority when selecting experiments to replicate and when performing the replication. We conclude that systematically improving three domains of validity – internal, external and translational – will result in a more efficient allocation of resources, will be more ethical, and will ultimately increase the chances of successful translation.
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spelling pubmed-78171762021-01-21 Improving preclinical studies through replications Drude, Natascha Ingrid Martinez Gamboa, Lorena Danziger, Meggie Dirnagl, Ulrich Toelch, Ulf eLife Medicine The purpose of preclinical research is to inform the development of novel diagnostics or therapeutics, and the results of experiments on animal models of disease often inform the decision to conduct studies in humans. However, a substantial number of clinical trials fail, even when preclinical studies have apparently demonstrated the efficacy of a given intervention. A number of large-scale replication studies are currently trying to identify the factors that influence the robustness of preclinical research. Here, we discuss replications in the context of preclinical research trajectories, and argue that increasing validity should be a priority when selecting experiments to replicate and when performing the replication. We conclude that systematically improving three domains of validity – internal, external and translational – will result in a more efficient allocation of resources, will be more ethical, and will ultimately increase the chances of successful translation. eLife Sciences Publications, Ltd 2021-01-12 /pmc/articles/PMC7817176/ /pubmed/33432925 http://dx.doi.org/10.7554/eLife.62101 Text en © 2021, Drude et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Medicine
Drude, Natascha Ingrid
Martinez Gamboa, Lorena
Danziger, Meggie
Dirnagl, Ulrich
Toelch, Ulf
Improving preclinical studies through replications
title Improving preclinical studies through replications
title_full Improving preclinical studies through replications
title_fullStr Improving preclinical studies through replications
title_full_unstemmed Improving preclinical studies through replications
title_short Improving preclinical studies through replications
title_sort improving preclinical studies through replications
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817176/
https://www.ncbi.nlm.nih.gov/pubmed/33432925
http://dx.doi.org/10.7554/eLife.62101
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